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18F-FDG/13N-ammonia cardiac PET findings in ATTR cardiac amyloidosis

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Journal of Nuclear Cardiology Aims and scope

Abstract

18F-flurodeoxyglycose (FDG)/13N-ammonia positron emission tomography/computed tomography (PET/CT) is frequently utilized to evaluate cardiac sarcoidosis (CS) but findings can reflect other forms of myocardial inflammation or altered myocardial metabolic activity. Herein, we present five cases where cardiac PET findings suggested CS, but right ventricular endomyocardial biopsy samples revealed ATTR-type cardiac amyloidosis.

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Abbreviations

ATTR-CM:

Transthyretin amyloid cardiomyopathy

CMR:

Cardiac magnetic resonance imaging

CS:

Cardiac sarcoidosis

EF:

Ejection fraction

EMBx:

Endomyocardial biopsy

18F-FDG:

18F-flurodeoxyglycose

GLS:

Global longitudinal strain

H/CL:

Heart to contralateral lung

LC-MS/MS:

Liquid chromatography-tandem mass spectrometry

LV:

Left ventricular

PET/CT:

Positron emission tomography/computed tomography

PVC:

Premature ventricular contraction

PYP:

99MTechnetium-pyrophosphate

SPECT/CT:

Single photon emission computed tomography/computed tomography

TTE:

Transthoracic echocardiogram

TTR:

Transthyretin

VT:

Ventricular tachycardia

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA

    Kathleen A. Young MD, Andrew N. Rosenbaum MD, Ian C. Chang MD, Grace Lin MD, Omar F. Abou Ezzeddine MD, CM, MS, Hayan Jouni MD, Panithaya Chareonthaitawee MD, Suraj Kapa MD, Martha Grogan MD & John P. Bois MD

  2. Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FLa, USA

    Melissa Lyle MD & Leslie T. Cooper MD

  3. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

    Melanie C. Bois MD

  4. Olmsted Medical Center, Rochester, MN, USA

    Lori Blauwet MD

Authors
  1. Kathleen A. Young MD
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  2. Melissa Lyle MD
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  3. Andrew N. Rosenbaum MD
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  4. Ian C. Chang MD
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  5. Grace Lin MD
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  6. Melanie C. Bois MD
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  7. Omar F. Abou Ezzeddine MD, CM, MS
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  8. Hayan Jouni MD
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  9. Panithaya Chareonthaitawee MD
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  10. Suraj Kapa MD
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  11. Martha Grogan MD
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  12. Leslie T. Cooper MD
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  13. Lori Blauwet MD
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  14. John P. Bois MD
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Corresponding author

Correspondence to John P. Bois MD.

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Young, K.A., Lyle, M., Rosenbaum, A.N. et al. 18F-FDG/13N-ammonia cardiac PET findings in ATTR cardiac amyloidosis. J. Nucl. Cardiol. 30, 726–735 (2023). https://doi.org/10.1007/s12350-021-02886-2

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  • DOI: https://doi.org/10.1007/s12350-021-02886-2

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