Skip to main content

Advertisement

SpringerLink
Log in

Cardiac imaging for the assessment of patients being evaluated for kidney or liver transplantation

  • CME ARTICLE REVIEW ARTICLE
  • Published:
Journal of Nuclear Cardiology Aims and scope

Abstract

Cardiac risk assessment prior to kidney and liver transplantation is controversial. Given the paucity of available organs, selecting appropriate recipients with favorable short- and long-term cardiovascular risk profile is crucial. Using noninvasive cardiac imaging tools to guide cardiovascular risk assessment and management can also be challenging and controversial. In this article, we address the burden of coronary artery disease among kidney and liver transplant candidates and review the literature pertaining to the diagnostic accuracy and the prognostic value of noninvasive cardiac imaging techniques in this population.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  1. Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof EL, Fleischmann KE, et al. ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery) Developed in Collaboration With the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. J Am Coll Cardiol 2007;50:1707-32.

    Article  PubMed  Google Scholar 

  2. Hendel RC, Berman DS, Di Carli MF, Heidenreich PA, Henkin RE, Pellikka PA, et al. ACCF/ASNC/ACR/AHA/ASE/SCCT/SCMR/SNM 2009 appropriate use criteria for cardiac radionuclide imaging: A report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the American Society of Nuclear Cardiology, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the Society of Cardiovascular Computed Tomography, the Society for Cardiovascular Magnetic Resonance, and the Society of Nuclear Medicine. Endorsed by the American College of Emergency Physicians. J Am Coll Cardiol 2009;53:2201-29.

    Article  PubMed  Google Scholar 

  3. Lentine KL, Costa SP, Weir MR, Robb JF, Fleisher LA, Kasiske BL, et al. Cardiac disease evaluation and management among kidney and liver transplantation candidates: A scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2012;60:434-80.

    Article  PubMed  Google Scholar 

  4. U.S. Renal Data System. USRDS 2013 annual data report: Atlas of chronic kidney disease and end-stage renal disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Disease; 2013. p. 2.

  5. Port FK, Wolfe RA, Mauger EA, Berling DP, Jiang K. COmparison of survival probabilities for dialysis patients vs cadaveric renal transplant recipients. J Am Med Assoc 1993;270:1339-43.

    Article  CAS  Google Scholar 

  6. Arend SM, Mallat MJ, Westendorp RJ, van der Woude FJ, van Es LA. Patient survival after renal transplantation; more than 25 years follow-up. Nephrol Dial Transplant 1997;12:1672-9.

    Article  CAS  PubMed  Google Scholar 

  7. Kumar N, Baker CS, Chan K, Duncan N, Malik I, Frankel A, et al. Cardiac survival after pre-emptive coronary angiography in transplant patients and those awaiting transplantation. Clin J Am Soc Nephrol 2011;6:1912-9.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Gowdak LH, de Paula FJ, Cesar LA, Martinez Filho EE, Ianhez LE, Krieger EM, et al. Screening for significant coronary artery disease in high-risk renal transplant candidates. Coron Artery Dis 2007;18:553-8.

    Article  PubMed  Google Scholar 

  9. Ojo AO, Hanson JA, Wolfe RA, Leichtman AB, Agodoa LY, Port FK. Long-term survival in renal transplant recipients with graft function. Kidney Int 2000;57:307-13.

    Article  CAS  PubMed  Google Scholar 

  10. Aakhus S, Dahl K, Wideroe TE. Cardiovascular disease in stable renal transplant patients in Norway: Morbidity and mortality during a 5-yr follow-up. Clin Transplant 2004;18:596-604.

    Article  PubMed  Google Scholar 

  11. Ducloux D, Kazory A, Chalopin JM. Predicting coronary heart disease in renal transplant recipients: A prospective study. Kidney Int 2004;66:441-7.

    Article  PubMed  Google Scholar 

  12. Jardine AG, Fellstrom B, Logan JO, Cole E, Nyberg G, Gronhagen-Riska C, et al. Cardiovascular risk and renal transplantation: Post hoc analyses of the Assessment of Lescol in Renal Transplantation (ALERT) Study. Am J Kidney Dis 2005;46:529-36.

    Article  PubMed  Google Scholar 

  13. Rigatto C, Foley R, Jeffery J, Negrijn C, Tribula C, Parfrey P. Electrocardiographic left ventricular hypertrophy in renal transplant recipients: Prognostic value and impact of blood pressure and anemia. J Am Soc Nephrol 2003;14:462-8.

    Article  PubMed  Google Scholar 

  14. Kasiske BL, Cangro CB, Hariharan S, Hricik DE, Kerman RH, Roth D, et al. The evaluation of renal transplantation candidates: Clinical practice guidelines. Am J Transplant 2001;1:3-95.

    PubMed  Google Scholar 

  15. Abbud-Filho M, Adams PL, Alberu J, Cardella C, Chapman J, Cochat P, et al. A report of the Lisbon Conference on the care of the kidney transplant recipient. Transplantation 2007;83:S1-22.

    Article  PubMed  Google Scholar 

  16. K/DOQI Workgroup. K/DOQI clinical practice guidelines for cardiovascular disease in dialysis patients. Am J Kidney Dis 2005;45:S1-153.

    Google Scholar 

  17. De Lima JJ, Sabbaga E, Vieira ML, de Paula FJ, Ianhez LE, Krieger EM, et al. Coronary angiography is the best predictor of events in renal transplant candidates compared with noninvasive testing. Hypertension 2003;42:263-8.

    Article  PubMed  Google Scholar 

  18. Hage FG, Smalheiser S, Zoghbi GJ, Perry GJ, Deierhoi M, Warnock D, et al. Predictors of survival in patients with end-stage renal disease evaluated for kidney transplantation. Am J Cardiol 2007;100:1020-5.

    Article  PubMed  Google Scholar 

  19. Jeloka TK, Ross H, Smith R, Huang M, Fenton S, Cattran D, et al. Renal transplant outcome in high-cardiovascular risk recipients. Clin Transplant 2007;21:609-14.

    Article  PubMed  Google Scholar 

  20. Aljaroudi W, Hermann D, Hage F, Heo J, Iskandrian AE. Safety of regadenoson in patients with end-stage renal disease. Am J Cardiol 2010;105:133-5.

    Article  CAS  PubMed  Google Scholar 

  21. Doukky R, Rangel MO, Wassouf M, Dick R, Alqaid A, Morales Demori R. The safety and tolerability of regadenoson in patients with end-stage renal disease: The first prospective evaluation. J Nucl Cardiol 2013;20:205-13.

    Article  PubMed  Google Scholar 

  22. Doukky R, Morales Demori R, Jain S, Kiriakos R, Mwansa V, Calvin JE. Attenuation of the side effect profile of regadenoson: A randomized double-blinded placebo-controlled study with aminophylline in patients undergoing myocardial perfusion imaging. “The ASSUAGE trial”. J Nucl Cardiol 2012;19:448-57.

    Article  PubMed  Google Scholar 

  23. Doukky R, Rangel MO, Dick R, Wassouf M, Alqaid A, Margeta B. Attenuation of the side effect profile of regadenoson: A randomized double-blind placebo-controlled study with aminophylline in patients undergoing myocardial perfusion imaging and have severe chronic kidney disease-the ASSUAGE-CKD trial. Int J Cardiovasc Imaging 2013;29:1029-37.

    Article  PubMed  Google Scholar 

  24. Wang LW, Fahim MA, Hayen A, Mitchell RL, Baines L, Lord S et al. Cardiac testing for coronary artery disease in potential kidney transplant recipients. Cochrane Database Syst Rev 2011;12:Cd008691.

  25. Greenwood JP, Maredia N, Younger JF, Brown JM, Nixon J, Everett CC, et al. Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): A prospective trial. Lancet 2012;379:453-60.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Rochitte CE, George RT, Chen MY, Arbab-Zadeh A, Dewey M, Miller JM, et al. Computed tomography angiography and perfusion to assess coronary artery stenosis causing perfusion defects by single photon emission computed tomography: The CORE320 study. Eur Heart J 2014;35:1120-30.

    Article  PubMed  Google Scholar 

  27. Tonino PA, De Bruyne B, Pijls NH, Siebert U, Ikeno F, van’ t Veer M, et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention. N Engl J Med 2009;360:213-24.

    Article  CAS  PubMed  Google Scholar 

  28. Iskandrian AS, Chae SC, Heo J, Stanberry CD, Wasserleben V, Cave V. Independent and incremental prognostic value of exercise single-photon emission computed tomographic (SPECT) thallium imaging in coronary artery disease. J Am Coll Cardiol 1993;22:665-70.

    Article  CAS  PubMed  Google Scholar 

  29. McArdle BA, Dowsley TF, deKemp RA, Wells GA, Beanlands RS. Does rubidium-82 PET have superior accuracy to SPECT perfusion imaging for the diagnosis of obstructive coronary disease? A systematic review and meta-analysis. J Am Coll Cardiol 2012;60:1828-37.

    Article  Google Scholar 

  30. McCullough PA. Coronary artery disease. Clin J Am Soc Nephrol 2007;2:611-6.

    Article  CAS  PubMed  Google Scholar 

  31. Mao J, Karthikeyan V, Poopat C, Song T, Pantelic M, Chattahi J, et al. Coronary computed tomography angiography in dialysis patients undergoing pre-renal transplantation cardiac risk stratification. Cardiol J 2010;17:349-61.

    PubMed  Google Scholar 

  32. Jug B, Kadakia J, Gupta M, Papazian J, Derakhshani A, Koplik S, et al. Coronary calcifications and plaque characteristics in patients with end-stage renal disease: A computed tomographic study. Coron Artery Dis 2013;24:501-8.

    Article  PubMed  Google Scholar 

  33. Sharples EJ, Pereira D, Summers S, Cunningham J, Rubens M, Goldsmith D, et al. Coronary artery calcification measured with electron-beam computerized tomography correlates poorly with coronary artery angiography in dialysis patients. Am J Kidney Dis 2004;43:313-9.

    Article  PubMed  Google Scholar 

  34. Rosario MA, Lima JJ, Parga JR, Avila LF, Gowdak LH, Lemos PA et al. Coronary calcium score as predictor of stenosis and events in pretransplant renal chronic failure. Arquivos brasileiros de cardiologia 2010;94:236-43, 52-60, 9-47.

  35. Park MY, Choi SJ, Kim JK, Hwang SD, Suh JON, Seo HS, et al. Use of multidetector computed tomography for evaluating coronary artery disease in patients undergoing dialysis. Nephrology 2011;16:285-9.

    Article  PubMed  Google Scholar 

  36. Robinson J, Tan AU, Wilensky RL, Matthai W, Munoz M, Rosas SE. Electron-beam computerized tomography correlates with coronary angiogram in chronic kidney disease patients. Am J Nephrol 2007;27:247-52.

    Article  PubMed  Google Scholar 

  37. Haydar AA, Covic A, Colhoun H, Rubens M, Goldsmith DJ. Coronary artery calcification and aortic pulse wave velocity in chronic kidney disease patients. Kidney Int 2004;65:1790-4.

    Article  PubMed  Google Scholar 

  38. Wong CF, Little MA, Vinjamuri S, Hammad A, Harper JM. Technetium myocardial perfusion scanning in prerenal transplant evaluation in the United Kingdom. Transplant Proc 2008;40:1324-8.

    Article  CAS  PubMed  Google Scholar 

  39. Patel AD, Abo-Auda WS, Davis JM, Zoghbi GJ, Deierhoi MH, Heo J, et al. Prognostic value of myocardial perfusion imaging in predicting outcome after renal transplantation. Am J Cardiol 2003;92:146-51.

    Article  PubMed  Google Scholar 

  40. Chew CG, Unger S, Shakib S. Value of myocardial perfusion imaging in renal transplant evaluation. Nephrology (Carlton, VIC). 2013;18:376-81.

    Article  Google Scholar 

  41. Murthy VL, Naya M, Foster CR, Hainer J, Gaber M, Dorbala S, et al. Coronary vascular dysfunction and prognosis in patients with chronic kidney disease. JACC Cardiovasc Imaging 2012;5:1025-34.

    Article  PubMed Central  PubMed  Google Scholar 

  42. Bergeron S, Hillis GS, Haugen EN, Oh JK, Bailey KR, Pellikka PA. Prognostic value of dobutamine stress echocardiography in patients with chronic kidney disease. Am Heart J 2007;153:385-91.

    Article  PubMed  Google Scholar 

  43. Tita C, Karthikeyan V, Stroe A, Jacobsen G, Ananthasubramaniam K. Stress echocardiography for risk stratification in patients with end-stage renal disease undergoing renal transplantation. J Am Soc Echocardiogr 2008;21:321-6.

    Article  PubMed  Google Scholar 

  44. Rabbat CG, Treleaven DJ, Russell JD, Ludwin D, Cook DJ. Prognostic value of myocardial perfusion studies in patients with end-stage renal disease assessed for kidney or kidney-pancreas transplantation: A meta-analysis. J Am Soc Nephrol 2003;14:431-9.

    Article  PubMed  Google Scholar 

  45. de Bie MK, Buiten MS, Gaasbeek A, Boogers MJ, Roos CJ, Schuijf JD, et al. CT coronary angiography is feasible for the assessment of coronary artery disease in chronic dialysis patients, despite high average calcium scores. PLoS ONE 2013;8:e67936.

    Article  PubMed Central  PubMed  Google Scholar 

  46. Shantouf RS, Budoff MJ, Ahmadi N, Ghaffari A, Flores F, Gopal A, et al. Total and individual coronary artery calcium scores as independent predictors of mortality in hemodialysis patients. Am J Nephrol 2010;31:419-25.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  47. Rakhit DJ, Marwick TH, Armstrong KA, Johnson DW, Leano R, Isbel NM. Effect of aggressive risk factor modification on cardiac events and myocardial ischaemia in patients with chronic kidney disease. Heart 2006;92:1402-8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  48. Gill JS, Ma I, Landsberg D, Johnson N, Levin A. Cardiovascular events and investigation in patients who are awaiting cadaveric kidney transplantation. J Am Soc Nephrol 2005;16:808-16.

    Article  PubMed  Google Scholar 

  49. Xia VW, Taniguchi M, Steadman RH. The changing face of patients presenting for liver transplantation. Curr Opin Organ Transplant 2008;13:280-4.

    Article  PubMed  Google Scholar 

  50. Ehtisham J, Altieri M, Salame E, Saloux E, Ollivier I, Hamon M. Coronary artery disease in orthotopic liver transplantation: Pretransplant assessment and management. Liver Transplant 2010;16:550-7.

    Google Scholar 

  51. Jacob M, Copley LP, Lewsey JD, Gimson A, Rela M, van der Meulen JH. Functional status of patients before liver transplantation as a predictor of posttransplant mortality. Transplantation 2005;80:52-7.

    Article  PubMed  Google Scholar 

  52. Carey WD, Dumot JA, Pimentel RR, Barnes DS, Hobbs RE, Henderson JM, et al. The prevalence of coronary artery disease in liver transplant candidates over age 50. Transplantation 1995;59:859-64.

    Article  CAS  PubMed  Google Scholar 

  53. Gk H. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005;352:1685-95.

    Article  Google Scholar 

  54. Appleton CPHT. Reducing coronary artery disease events in liver transplant patients: Moving toward identifying the vulnerable patient. Liver Transplant 2008;14:1691-3.

    Article  Google Scholar 

  55. Kadayifci A, Tan V, Ursell PC, Merriman RB, Bass NM. Clinical and pathologic risk factors for atherosclerosis in cirrhosis: A comparison between NASH-related cirrhosis and cirrhosis due to other aetiologies. J Hepatol 2008;49:595-9.

    Article  PubMed  Google Scholar 

  56. Plotkin JS, Scott VL, Pinna A, Dobsch BP, De Wolf AM, Kang Y. Morbidity and mortality in patients with coronary artery disease undergoing orthotopic liver transplantation. Liver Transplant Surg 1996;2:426-30.

    Article  CAS  Google Scholar 

  57. Diedrich DA, Findlay JY, Harrison BA, Rosen CB. Influence of coronary artery disease on outcomes after liver transplantation. Transplant Proc 2008;40:3554-7.

    Article  CAS  PubMed  Google Scholar 

  58. Raval Z, Harinstein ME, Skaro AI, Erdogan A, DeWolf AM, Shah SJ, et al. Cardiovascular risk assessment of the liver transplant candidate. J Am Coll Cardiol 2011;58:223-31.

    Article  PubMed  Google Scholar 

  59. Moller S, Henriksen JH. Cirrhotic cardiomyopathy: A pathophysiological review of circulatory dysfunction in liver disease. Heart 2002;87:9-15.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  60. Moller S, Dumcke CW, Krag A. The heart and the liver. Exp Rev Gastroenterol Hepatol 2009;3:51-64.

    Article  Google Scholar 

  61. Murray KF, Carithers RL Jr. AASLD practice guidelines: Evaluation of the patient for liver transplantation. Hepatology 2005;41:1407-32.

    Article  PubMed  Google Scholar 

  62. Williams K, Lewis JF, Davis G, Geiser EA. Dobutamine stress echocardiography in patients undergoing liver transplantation evaluation. Transplantation 2000;69:2354-6.

    Article  CAS  PubMed  Google Scholar 

  63. Davidson CJ, Gheorghiade M, Flaherty JD, Elliot MD, Reddy SP, Wang NC, et al. Predictive value of stress myocardial perfusion imaging in liver transplant candidates. Am J Cardiol 2002;89:359-60.

    Article  PubMed  Google Scholar 

  64. Aljaroudi W, Iqbal F, Koneru J, Bhambhvani P, Heo J, Iskandrian AE. Safety of regadenoson in patients with end-stage liver disease. J Nucl Cardiol 2011;18:90-5.

    Article  PubMed  Google Scholar 

  65. Bhutani S, Tobis J, Gevorgyan R, Sinha A, Suh W, Honda HM, et al. Accuracy of stress myocardial perfusion imaging to diagnose coronary artery disease in end stage liver disease patients. Am J Cardiol 2013;111:1057-61.

    Article  PubMed  Google Scholar 

  66. Aydinalp A, Bal U, Atar I, Ertan C, Aktas A, Yildirir A, et al. Value of stress myocardial perfusion scanning in diagnosis of severe coronary artery disease in liver transplantation candidates. Transplant Proc 2009;41:3757-60.

    Article  CAS  PubMed  Google Scholar 

  67. Shanoudy H, Raggi P, Beller GA, Soliman A, Ammermann EG, Kastner RJ, et al. Comparison of technetium-99m tetrofosmin and thallium-201 single-photon emission computed tomographic imaging for detection of myocardial perfusion defects in patients with coronary artery disease. J Am Coll Cardiol 1998;31:331-7.

    Article  CAS  PubMed  Google Scholar 

  68. Plotkin JS, Benitez RM, Kuo PC, Njoku MJ, Ridge LA, Lim JW, et al. Dobutamine stress echocardiography for preoperative cardiac risk stratification in patients undergoing orthotopic liver transplantation. Liver Transplant Surg 1998;4:253-7.

    Article  CAS  Google Scholar 

  69. Donovan CL, Marcovitz PA, Punch JD, Bach DS, Brown KA, Lucey MR, et al. Two-dimensional and dobutamine stress echocardiography in the preoperative assessment of patients with end-stage liver disease prior to orthotopic liver transplantation. Transplantation 1996;61:1180-8.

    Article  CAS  PubMed  Google Scholar 

  70. Harinstein ME, Flaherty JD, Ansari AH, Robin J, Davidson CJ, Rossi JS, et al. Predictive value of dobutamine stress echocardiography for coronary artery disease detection in liver transplant candidates. Am J Transplant 2008;8:1523-8.

    Article  CAS  PubMed  Google Scholar 

  71. Patel S, Kiefer TL, Ahmed A, Ali ZA, Tremmel JA, Lee DP, et al. Comparison of the frequency of coronary artery disease in alcohol-related versus non-alcohol-related endstage liver disease. Am J Cardiol 2011;108:1552-5.

    Article  PubMed  Google Scholar 

  72. Nguyen P, Plotkin J, Fishbein TM, Laurin JM, Satoskar R, Shetty K, et al. Dobutamine stress echocardiography in patients undergoing orthotopic liver transplantation: A pooled analysis of accuracy, perioperative and long term cardiovascular prognosis. Int J Cardiovasc Imaging 2013;29:1741-8.

    Article  PubMed  Google Scholar 

  73. Kemmer N, Case J, Chandna S, Neff GW. The role of coronary calcium score in the risk assessment of liver transplant candidates. Transplant Proc 2014;46:230-3.

    Article  CAS  PubMed  Google Scholar 

  74. McAvoy NC, Kochar N, McKillop G, Newby DE, Hayes PC. Prevalence of coronary artery calcification in patients undergoing assessment for orthotopic liver transplantation. Liver Transplant 2008;14:1725-31.

    Article  Google Scholar 

  75. Keeling AN, Flaherty JD, Davarpanah AH, Ambrosy A, Farrelly CT, Harinstein ME, et al. Coronary multidetector computed tomographic angiography to evaluate coronary artery disease in liver transplant candidates: Methods, feasibility and initial experience. J Cardiovasc Med (Hagerstown, MD) 2011;12:460-8.

    Article  Google Scholar 

  76. Jodocy D, Abbrederis S, Graziadei IW, Vogel W, Pachinger O, Feuchtner GM, et al. Coronary computer tomographic angiography for preoperative risk stratification in patients undergoing liver transplantation. Eur J Radiol 2012;81:2260-4.

    Article  PubMed  Google Scholar 

  77. Chae WY, Hwang S, Yoon YI, Kang MC, Moon DB, Song GW, et al. Clinical value of preoperative coronary risk assessment by computed tomographic arteriography prior to adult living donor liver transplantation. Transplant Proc 2012;44:415-7.

    Article  PubMed  Google Scholar 

  78. Cassagneau P, Jacquier A, Giorgi R, Amabile N, Gaubert JY, Cohen F, et al. Prognostic value of preoperative coronary computed tomography angiography in patients treated by orthotopic liver transplantation. Eur J Gastroenterol Hepatol 2012;24:558-62.

    Article  PubMed  Google Scholar 

  79. Poulin MF, Chan EY, Ibrahim SA, Doukky R. Integrating coronary computed tomographic angiography in the evaluation of liver transplant candidates: A novel approach [Abstract]. J Nuc Cardiol 2014;21:802.

  80. Reddy ST, Thai NL, Fakhri AA, Oliva J, Tom KB, Dishart MK, et al. Exploratory use of cardiovascular magnetic resonance imaging in liver transplantation: A one-stop shop for preoperative cardiohepatic evaluation. Transplantation 2013;96:827-33.

    Article  PubMed  Google Scholar 

  81. Zoghbi GJ, Patel AD, Ershadi RE, Heo J, Bynon JS, Iskandrian AE. Usefulness of preoperative stress perfusion imaging in predicting prognosis after liver transplantation. Am J Cardiol 2003;92:1066-71.

    Article  PubMed  Google Scholar 

  82. Bradley SM, Soine LA, Caldwell JH, Goldberg SL. Screening stress myocardial perfusion imaging and eligibility for liver transplantation. Am J Cardiol 2010;105:1010-3.

    Article  PubMed  Google Scholar 

  83. Safadi A, Homsi M, Maskoun W, Lane KA, Singh I, Sawada SG, et al. Perioperative risk predictors of cardiac outcomes in patients undergoing liver transplantation surgery. Circulation 2009;120:1189-94.

    Article  PubMed  Google Scholar 

  84. Findlay JY, Keegan MT, Pellikka PP, Rosen CB, Plevak DJ. Preoperative dobutamine stress echocardiography, intraoperative events, and intraoperative myocardial injury in liver transplantation. Transplant Proc 2005;37:2209-13.

    Article  CAS  PubMed  Google Scholar 

  85. Tsutsui JM, Mukherjee S, Elhendy A, Xie F, Lyden ER, O’Leary E, et al. Value of dobutamine stress myocardial contrast perfusion echocardiography in patients with advanced liver disease. Liver Transplant 2006;12:592-9.

    Article  Google Scholar 

  86. Umphrey LG, Hurst RT, Eleid MF, Lee KS, Reuss CS, Hentz JG, et al. Preoperative dobutamine stress echocardiographic findings and subsequent short-term adverse cardiac events after orthotopic liver transplantation. Liver Transplant 2008;14:886-92.

    Article  Google Scholar 

  87. Gowdak LH, de Paula FJ, De Oliveira AL, Arantes RL, Cesar LA, Ramires JA, et al. Non-invasive screening for coronary artery disease in renal transplant candidates with diabetes is influenced by gender. Sophia Antipolis: European Society of Cardiology; 2010.

    Google Scholar 

  88. Boudreau RJ, Strony JT, duCret RP, Kuni CC, Wang Y, Wilson RF, et al. Perfusion thallium imaging of type I diabetes patients with end stage renal disease: Comparison of oral and intravenous dipyridamole administration. Radiology 1990;175:103-5.

    Article  CAS  PubMed  Google Scholar 

  89. Worthley MI, Unger SA, Mathew TH, Russ GR, Horowitz JD. Usefulness of tachycardic-stress perfusion imaging to predict coronary artery disease in high-risk patients with chronic renal failure. Am J Cardiol 2003;92:1318-20.

    Article  PubMed  Google Scholar 

  90. Schmidt A, Stefenelli T, Schuster E, Mayer G. Informational contribution of noninvasive screening tests for coronary artery disease in patients on chronic renal replacement therapy. Am J Kidney Dis 2001;37:56-63.

    Article  CAS  PubMed  Google Scholar 

  91. Vandenberg BF, Rossen JD, Grover-McKay M, Shammas NW, Burns TL, Rezai K. Evaluation of diabetic patients for renal and pancreas transplantation: Noninvasive screening for coronary artery disease using radionuclide methods. Transplantation 1996;62:1230-5.

    Article  CAS  PubMed  Google Scholar 

  92. Dahan M, Viron BM, Faraggi M, Himbert DL, Lagallicier BJ, Kolta AM, et al. Diagnostic accuracy and prognostic value of combined dipyridamole-exercise thallium imaging in hemodialysis patients. Kidney Int 1998;54:255-62.

    Article  CAS  PubMed  Google Scholar 

  93. Sharma R, Mehta RL, Brecker SJ, Gaze DC, Gregson H, Streather CP, et al. The diagnostic and prognostic value of tissue Doppler imaging during dobutamine stress echocardiography in end-stage renal disease. Coron Artery Dis 2009;20:230-7.

    Article  PubMed  Google Scholar 

  94. Sharma R, Pellerin D, Gaze DC, Gregson H, Streather CP, Collinson PO, et al. Dobutamine stress echocardiography and the resting but not exercise electrocardiograph predict severe coronary artery disease in renal transplant candidates. Nephrol Dial Transplant 2005;20:2207-14.

    Article  PubMed  Google Scholar 

  95. Ferreira PA, de Lima VC, Campos Filho O, Gil MA, Cordovil A, Machado CV, et al. Feasibility, safety and accuracy of dobutamine/atropine stress echocardiography for the detection of coronary artery disease in renal transplant candidates. Arq Bras Cardiol 2007;88:45-51.

    Article  PubMed  Google Scholar 

  96. Cai Q, Serrano R, Kalyanasundaram A, Shirani J. A preoperative echocardiographic predictive model for assessment of cardiovascular outcome after renal transplantation. J Am Soc Echocardiogr 2010;23:560-6.

    Article  PubMed  Google Scholar 

  97. West JC, Napoliello DA, Costello JM, Nassef LA, Butcher RJ, Hartle JE, et al. Preoperative dobutamine stress echocardiography versus cardiac arteriography for risk assessment prior to renal transplantation. Transplant Int 2000;13:S27-30.

    Article  Google Scholar 

  98. Herzog CA, Marwick TH, Pheley AM, White CW, Rao VK, Dick CD. Dobutamine stress echocardiography for the detection of significant coronary artery disease in renal transplant candidates. Am J Kidney Dis 1999;33:1080-90.

    Article  CAS  PubMed  Google Scholar 

  99. Garcia-Canton C, Culegras C, Hernandez-Briz MJ, Palomar R, Moreno A, et al. Dobutamine stress echocardiography and stress 99M-technetium methoxyisobutylisonitrile SPECT in the assessment of coronary artery disease in kidney transplant candidates [Abstract]. J Am Soc Nephrol 1998;9:708A.

    Google Scholar 

  100. Gang S, Dabhi M, Rajapurkar MM. Ischaemia imaging in type 2 diabetic kidney transplant candidates—is coronary angiography essential? Nephrol Dial Transplant 2007;22:2334-8.

    Article  PubMed  Google Scholar 

Download references

Disclosures

Rami Doukky received research support from Astellas Pharma U.S. and served on the Advisory Board of Astellas Pharma U.S. Other authors have no conflicts.

Author information

Authors and Affiliations

  1. Division of Cardiology, Rush University Medical Center, Chicago, IL, USA

    Kalindi Parikh MD, Andrew Appis MD & Rami Doukky MD, MSc, FACC, FASNC

  2. Division of Adult Cardiology, John H. Stroger, Jr. Hospital of Cook County, 1901 W. Harrison St, Suite # 3620, Chicago, IL, 60612, USA

    Rami Doukky MD, MSc, FACC, FASNC

Authors
  1. Kalindi Parikh MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrew Appis MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rami Doukky MD, MSc, FACC, FASNC
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rami Doukky MD, MSc, FACC, FASNC.

Additional information

See related editorial, doi:10.1007/s12350-014-0006-2.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Parikh, K., Appis, A. & Doukky, R. Cardiac imaging for the assessment of patients being evaluated for kidney or liver transplantation. J. Nucl. Cardiol. 22, 282–296 (2015). https://doi.org/10.1007/s12350-014-9997-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12350-014-9997-y

Keywords

Search

Navigation