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Rationale and design of the dual-energy computed tomography for ischemia determination compared to “gold standard” non-invasive and invasive techniques (DECIDE-Gold): A multicenter international efficacy diagnostic study of rest-stress dual-energy computed tomography angiography with perfusion

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Dual-energy CT (DECT) has potential to improve myocardial perfusion for physiologic assessment of coronary artery disease (CAD). Diagnostic performance of rest-stress DECT perfusion (DECTP) is unknown.

Objective

DECIDE-Gold is a prospective multicenter study to evaluate the accuracy of DECT to detect hemodynamic (HD) significant CAD, as compared to fractional flow reserve (FFR) as a reference standard.

Methods

Eligible participants are subjects with symptoms of CAD referred for invasive coronary angiography (ICA). Participants will undergo DECTP, which will be performed by pharmacological stress, and participants will subsequently proceed to ICA and FFR. HD-significant CAD will be defined as FFR ≤ 0.80. In those undergoing myocardial stress imaging (MPI) by positron emission tomography (PET), single photon emission computed tomography (SPECT) or cardiac magnetic resonance (CMR) imaging, ischemia will be graded by % ischemic myocardium. Blinded core laboratory interpretation will be performed for CCTA, DECTP, MPI, ICA, and FFR.

Results

Primary endpoint is accuracy of DECTP to detect ≥1 HD-significant stenosis at the subject level when compared to FFR. Secondary and tertiary endpoints are accuracies of combinations of DECTP at the subject and vessel levels compared to FFR and MPI.

Conclusion

DECIDE-Gold will determine the performance of DECTP for diagnosing ischemia.

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Disclosures

This study was sponsored by the National Heart, Lung, and Blood Institute of the National Institutes of Health (Bethesda, MD) under Award R01 HL111141 and R01 HL118019 and by a generous gift from the Dalio Foundation and the Michael Wolk Foundation (New York, NY).

Author information

Authors and Affiliations

  1. Departments of Radiology, Weill Cornell Medical College, 413 E. 69th Street, Suite 108, New York, NY, 10021, USA

    Quynh A. Truong MD, MPH & James K. Min MD

  2. Dalio Institute of Cardiovascular Imaging, New York Presbyterian Hospital, New York, NY, USA

    Quynh A. Truong MD, MPH & James K. Min MD

  3. Department of Cardiology, VU Medical Center, Amsterdam, The Netherlands

    Paul Knaapen MD, PhD

  4. Centro Cardiologico Monzino, Milan, Italy

    Gianluca Pontone MD, PhD & Daniele Andreini MD, PhD

  5. Providence Health Care-St. Paul’s Hospital, University of British Columbia, Vancouver, Canada

    Jonathon Leipsic MD

  6. Diagnóstico Maipú, Buenos Aires, Argentina

    Patricia Carrascosa MD, PhD

  7. State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

    Bin Lu MD

  8. Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA

    Kelley Branch MD

  9. Division of Cardiology, Department of Medicine, Wexner Heart and Vascular Institute, The Ohio State University, Columbus, OH, USA

    Subha Raman MD

  10. Midwest Heart & Vascular Associates, Kansas City, MO, USA

    Stephen Bloom MD

Authors
  1. Quynh A. Truong MD, MPH
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  2. Paul Knaapen MD, PhD
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  3. Gianluca Pontone MD, PhD
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  4. Daniele Andreini MD, PhD
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  5. Jonathon Leipsic MD
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  6. Patricia Carrascosa MD, PhD
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  7. Bin Lu MD
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  8. Kelley Branch MD
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  9. Subha Raman MD
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  10. Stephen Bloom MD
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  11. James K. Min MD
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Corresponding author

Correspondence to James K. Min MD.

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Truong, Q.A., Knaapen, P., Pontone, G. et al. Rationale and design of the dual-energy computed tomography for ischemia determination compared to “gold standard” non-invasive and invasive techniques (DECIDE-Gold): A multicenter international efficacy diagnostic study of rest-stress dual-energy computed tomography angiography with perfusion. J. Nucl. Cardiol. 22, 1031–1040 (2015). https://doi.org/10.1007/s12350-014-0035-x

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  • DOI: https://doi.org/10.1007/s12350-014-0035-x

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