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A case of hepatosplenic cat scratch disease with hemophagocytic lymphohistiocytosis

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Abstract

Cat scratch disease (CSD) is associated with Bartonella henselae (B. henselae) infection caused by cat scratches or bites. It typically presents with lymphadenitis and fever. However, there are atypical cases such as hepatosplenic CSD, which presents with specific lesions in the liver and spleen. Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe multisystem disorder triggered by infections, cancers, or autoimmune diseases. We experienced a rare case of hepatosplenic CSD with HLH in a non-immunocompromised adult. A 78-year-old woman complained of fever and fatigue. Laboratory tests revealed anemia and liver dysfunction; abdominal contrast-enhanced computed tomography (CT) revealed splenomegaly and nodular hypodense areas in the spleen. In addition, the levels of ferritin and serum soluble IL-2R were markedly elevated, so clinical diagnosis of HLH was made. Positron emission tomography/CT revealed diffuse fluorodeoxyglucose uptake in the liver and spleen suggesting malignant lymphoma, while the pathological findings from liver biopsy suggested infectious diseases. Although she had no cat bites and scratches, she had many cats; therefore, serum B. henselae antibody titers were measured. The B. henselae IgG and IgM titer were 1:128 and 1:20; thus, she was diagnosed with hepatosplenic CSD. Patients with hepatosplenic nodular lesions and contact with cats should be considered for this disease.

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Authors and Affiliations

  1. Department of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan

    Daisuke Minezaki, Mizuki Endo, Tomoko Saito, Tomoko Tokumaru, Masao Iwao, Mie Arakawa, Koichi Honda, Kazuhiro Mizukami, Masaaki Kodama & Kazunari Murakami

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  1. Daisuke Minezaki
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  2. Mizuki Endo
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  3. Tomoko Saito
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  4. Tomoko Tokumaru
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  5. Masao Iwao
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  6. Mie Arakawa
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  7. Koichi Honda
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  8. Kazuhiro Mizukami
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  9. Masaaki Kodama
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  10. Kazunari Murakami
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Correspondence to Mizuki Endo.

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Minezaki, D., Endo, M., Saito, T. et al. A case of hepatosplenic cat scratch disease with hemophagocytic lymphohistiocytosis. Clin J Gastroenterol 16, 871–876 (2023). https://doi.org/10.1007/s12328-023-01840-8

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  • DOI: https://doi.org/10.1007/s12328-023-01840-8

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