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A case of immunoglobulin G4-related sclerosing mesenteritis without other organ involvement

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Abstract

A 64-year-old man presented to our hospital with abdominal pain and 4–5 episodes of watery diarrhea per day for 2 months. Abdominal ultrasound examination revealed a mass in the peritoneal cavity, and computed tomography showed a 13.4 cm mass in the mesentery and a 3 cm mass in the mesocolon. The patient underwent laparoscopic partial resection for diagnosis. Microscopically, abundant fibrosis and numerous immunoglobulin (Ig) G4-positive plasma cells were observed. The serum level of IgG4 was 665 mg/dl postoperatively. These findings suggested that the lesion was consistent with IgG4-related sclerosing mesenteritis. Oral steroids resulted in rapid disappearance of symptoms and a decrease in masses. Recently, sclerosing mesenteritis are reported as IgG4-related disease or mimicking IgG4-related disease but multiple lesions rarely occur in the same organ. We report a case of IgG4-related sclerosing mesenteritis with multiple lesions without involvement of other organs, such as the pancreas and salivary glands.

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

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Authors and Affiliations

  1. Department of Gastroenterology, Kagoshima Kouseiren Hospital, 1-13-1 Yojiro, Kagoshima, 890-0062, Japan

    Masaya Kozono, Yoshio Fukuda & Koichi Tokushige

  2. Department of Surgery, Kagoshima Kouseiren Hospital, 1-13-1 Yojiro, Kagoshima, 890-0062, Japan

    Kiyokazu Hiwatashi & Masahiko Sakoda

  3. Department of Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan

    Michiyo Higashi

  4. Department of Human and Environmental Sciences, Digestive and Lifestyle Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan

    Shiroh Tanoue, Kanna Kiyama, Kenichi Jikuya, Machiko Kawahira, Makoto Hinokuchi, Hiromichi Iwaya, Shiho Arima, Shinichi Hashimoto & Akio Ido

Authors
  1. Masaya Kozono
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  2. Shiroh Tanoue
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  11. Yoshio Fukuda
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  13. Michiyo Higashi
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  14. Koichi Tokushige
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  15. Akio Ido
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by MK, ST, KK and KJ. The first draft of the manuscript was written by MK and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Shiroh Tanoue.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from the patient.

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Kozono, M., Tanoue, S., Kiyama, K. et al. A case of immunoglobulin G4-related sclerosing mesenteritis without other organ involvement. Clin J Gastroenterol 14, 1411–1418 (2021). https://doi.org/10.1007/s12328-021-01451-1

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  • DOI: https://doi.org/10.1007/s12328-021-01451-1

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