Abstract
Eosinophilic gastroenteritis (EGE) is a chronic allergic disorder characterized by infiltration of eosinophils in the gastrointestinal (GI) tract and hypereosinophilia. Although T helper type 2 (Th2) responses play pathogenic roles in EGE, roles of innate immunity cytokines including IL-6 and TNF-α have been poorly defined. Here, we describe a case of EGE exhibiting accumulation of eosinophils in the upper GI mucosa and hypereosinophilia. Induction of remission by prednisolone reduced expression levels not only of Th2 cytokines but also of IL-6 and TNF-α in the GI mucosa. Moreover, induction of remission was accompanied by a marked reduction in serum levels of chemokine C–C motif ligand 17 (CCL17, TARC), IL-6 and TNF-α, implicating that both Th2 and innate immune responses were involved in the development of EGE in this case. Collectively, this case suggests possible involvement of IL-6 and TNF-α in the development of EGE.
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Funding
This work was supported by a Grant-in-Aid for Scientific Research (19K08455) from the Japan Society for the Promotion of Science and grants from the Takeda Science Foundation, Smoking Research Foundation, Yakult Bio-Science Foundation, and SENSHIN Medical Research Foundation.
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Ikue Sekai, Tomohiro Watanabe, Keisuke Yoshikawa, Ryutaro Takada, Akane Hara, Tomoe Yoshikawa, Ken Kamata, Kosuke Minaga, and Masatoshi Kudo declare that they have no conflicts of interest.
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Sekai, I., Watanabe, T., Yoshikawa, K. et al. A case with eosinophilic gastroenteritis exhibiting enhanced TNF-α and IL-6 responses. Clin J Gastroenterol 14, 511–516 (2021). https://doi.org/10.1007/s12328-020-01320-3
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DOI: https://doi.org/10.1007/s12328-020-01320-3