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A case of gallbladder adenocarcinoma arising in association with intracystic papillary neoplasm (ICPN) with abundant mucin production

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Abstract

Intracystic papillary neoplasm (ICPN) of the gallbladder is a rare clinicopathological entity with a wide range of malignant potentials. Here, we report a case of mucin-producing gallbladder carcinoma possibly derived from ICPN. A 78-year-old female patient was referred to our hospital for examination of jaundice. Abdominal CT showed dilated biliary trees and a contrast-enhanced large polypoid mass in the gallbladder. Duodenoscopy showed a large amount of mucin extravasating from the ampulla of Vater. Bile cytology showed no evidence of malignancy. Under the diagnosis of mucin-producing gallbladder tumor, we performed laparoscopic cholecystectomy. Macroscopically, there was a large papillary tumor throughout the entire gallbladder mucosa. Pathological examinations showed a gallbladder adenocarcinoma localized to the mucosa in association with ICPN. Immunohistochemical analysis of the tumor revealed positive staining for MUC2 and MUC5AC but negative for MUC1 and MUC6, suggestive of the intestinal type.

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Abbreviations

ICPN:

Intracholecystic papillary–tubular neoplasm

IPNB:

Intraductal papillary neoplasm of the bile duct

IPMN:

Intraductal papillary mucinous neoplasm

US:

Ultrasonography

CT:

Computed tomography

ERC:

Endoscopic retrograde cholangiography

CEA:

Carcinoembryonic antigen

CA19-9:

Carbohydrate antigen 19-9

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Acknowledgements

We would like to thank Editage (www.editage.com) for English language editing.

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Authors and Affiliations

  1. Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan

    Takuya Oba, Norihiro Sato, Toshihisa Tamura, Masahiro Komeda, Yasuhiro Adachi & Keiji Hirata

  2. Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

    Atsuji Matsuyama

Authors
  1. Takuya Oba
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  2. Norihiro Sato
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  3. Toshihisa Tamura
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  4. Masahiro Komeda
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  5. Yasuhiro Adachi
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  6. Atsuji Matsuyama
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  7. Keiji Hirata
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Correspondence to Takuya Oba.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from the patient for inclusion in this study.

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Oba, T., Sato, N., Tamura, T. et al. A case of gallbladder adenocarcinoma arising in association with intracystic papillary neoplasm (ICPN) with abundant mucin production. Clin J Gastroenterol 14, 319–324 (2021). https://doi.org/10.1007/s12328-020-01233-1

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  • DOI: https://doi.org/10.1007/s12328-020-01233-1

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