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Surgically resected pancreatic metastasis from nasal malignant melanoma: case report and literature review

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Abstract

A 13-mm mass was observed in the pancreatic head of a 70-year-old woman who had undergone melanoma resection in the nasal cavity 10 years earlier. Endoscopic ultrasonography (EUS) showed that the mass consisted of multiple hypoechoic nodules. EUS-guided fine needle aspiration and pancreatic juice cytologies revealed neoplastic cells positive for HMB45 and melan-A staining with a few melanin granules, indicating the presence of a metastatic malignant melanoma. These additional stainings were evaluated after surgery. In the surgically resected specimen, the mass had multiple nodule-like structures, some of which were brown colored. Immunocytochemistry and electronic microscopy findings confirmed the diagnosis of malignant melanoma. Microscopic findings were similar to the nasal specimen; therefore, the pancreatic lesion was considered to be a metastasis from the nasal cavity.

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Authors and Affiliations

  1. Department of Gastroenterology, Sendai City Medical Center, Tsurugaya 5-22-1, Miyagino-ku, Sendai, Miyagi, Japan

    Yoshihide Kanno, Yutaka Noda, Shinsuke Koshita, Takahisa Ogawa, Kaori Masu, Masaya Oikawa, Takaho Okada, Naoya Akazawa, Takashi Sawai & Kei Ito

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  1. Yoshihide Kanno
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  2. Yutaka Noda
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  3. Shinsuke Koshita
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  4. Takahisa Ogawa
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  5. Kaori Masu
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  6. Masaya Oikawa
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  7. Takaho Okada
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  8. Naoya Akazawa
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Correspondence to Yoshihide Kanno.

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Kanno, Y., Noda, Y., Koshita, S. et al. Surgically resected pancreatic metastasis from nasal malignant melanoma: case report and literature review. Clin J Gastroenterol 12, 372–381 (2019). https://doi.org/10.1007/s12328-019-00936-4

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  • DOI: https://doi.org/10.1007/s12328-019-00936-4

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