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Gastric cancer associated with refractory cytomegalovirus gastritis

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Abstract

Cytomegalovirus (CMV) sometimes causes gastritis, especially in immunocompromised patients, but whether CMV gastritis promotes the development of gastric cancer is unknown. Here, we report a case of gastric cancer that developed in the presence of CMV gastritis, which had been present for at least 4 years and was refractory to treatment. An 80-year-old woman had noted epigastric discomfort and appetite loss. Esophagogastroduodenoscopy revealed a shallow geographical ulcer extending from the upper body to the pylorus. Histological findings of the biopsy and serology were suggestive of CMV gastritis. Serum anti-Helicobacter pylori antibody test was positive, suggesting co-infection with CMV and H. pylori. Her gastritis was unimproved with repeated antiviral therapy and eradication of H. pylori. Thirty months later, wide-spread gastric cancer had developed. We suggest the possibility that the addition of chronic inflammation of CMV infection to H. pylori-induced gastritis facilitated the development of gastric cancer.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-8602, Japan

    Masayuki Ueno, Yuichi Shimodate, Shumpei Yamamoto, Hiroshi Yamamoto & Motowo Mizuno

Authors
  1. Masayuki Ueno
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  2. Yuichi Shimodate
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  3. Shumpei Yamamoto
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  4. Hiroshi Yamamoto
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  5. Motowo Mizuno
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Corresponding author

Correspondence to Masayuki Ueno.

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The authors declare that they have no conflict of interest.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from all patients for being included in the study.

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Ueno, M., Shimodate, Y., Yamamoto, S. et al. Gastric cancer associated with refractory cytomegalovirus gastritis. Clin J Gastroenterol 10, 498–502 (2017). https://doi.org/10.1007/s12328-017-0773-9

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  • DOI: https://doi.org/10.1007/s12328-017-0773-9

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