Abstract
We herein report two patients with mantle cell lymphoma (MCL), who had isolated mass and multiple lymphomatous polyposis (MLP) in the gastrointestinal tract. In case 1, esophagogastroduodenoscopy revealed a protruding mass in the duodenum and double-balloon endoscopy disclosed numerous polypoid lesions in the ileum. Case 2 had polyposis in the duodenum and a large mass-forming lesion in the ascending colon. Based on the histologic and immunohistochemical findings of the biopsy specimens, the diagnosis of MCL was made in both patients. A combination of isolated mass and MLP is considered as characteristic endoscopic findings of intestinal lesions of MCL.
Similar content being viewed by others
References
Swerdlow SH, Campo E, Seto M, et al. Mantle cell lymphoma. In: Swerdlow SH, Campo E, Harris NL, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC; 2008. p. 229–32.
Nakamura S, Müller-Hermelink HK, Delabie J, et al. B-cell lymphoma of the small intestine. In: Bosman FT, Carneiro F, Hruban RH, et al., editors. WHO classification of tumours of the digestive system. 4th ed. Lyon: IARC; 2010. p. 108–11.
Nakamura S, Matsumoto T, Iida M, et al. Primary gastrointestinal lymphoma in Japan: a clinicopathologic analysis of 455 patients with special reference to its time trends. Cancer. 2003;97:2462–73.
Iwamuro M, Okada H, Kawahara Y, et al. Endoscopic features and prognoses of mantle cell lymphoma with gastrointestinal involvement. World J Gastroenterol. 2010;16:4661–9.
Kim JH, Jung HW, Kang KJ, et al. Endoscopic findings in mantle cell lymphoma with gastrointestinal tract involvement. Acta Haematol. 2012;127:129–34.
Rodrigues S, Cardoso H, Macedo G. Mantle cell lymphoma presenting as multiple lymphomatous polyposis of the small bowel. Clin Gastroenterol Hepatol. 2013;11:e71.
Saito M, Miyazaki M, Tanino M, et al. 18F-FDG PET/CT imaging for a gastrointestinal mantle cell lymphoma with multiple lymphomatous polyposis. World J Gastroenterol. 2014;20:5141–6.
Saito M, Mori A, Irie T, et al. Endoscopic follow-up of 3 cases with gastrointestinal tract involvement of mantle cell lymphoma. Intern Med. 2010;49:231–5.
Michopoulos S, Petraki K, Matsouka C, et al. Mantle-cell lymphoma (multiple lymphomatous polyposis) of the entire GI tract. J Clin Oncol. 2008;26:1555–7.
Moussaide G, Kazemi A, Mitre R, Mitre MC. Mantle cell lymphoma: a rare cause of a solitary duodenal mass. BMJ Case Rep. 2014. doi:10.1136/bcr-2014-203823.
Vignote ML, Chicano M, Rodríguez FJ, et al. Multiple lymphomatous polyposis of the GI tract: report of a case and review. Gastrointest Endosc. 2002;56:579–82.
Tamura S, Ohkawauchi K, Yokoyama Y, et al. Non-multiple lymphomatous polyposis form of mantle cell lymphoma in the gastrointestinal tract. J Gastroenterol. 2004;39:995–1000.
Hotta K, Oyama T, Kitamura Y, et al. Mantle cell lymphoma presenting as multiple lymphomatous polyposis spreading widely to the small intestine and diagnosed by double-balloon endoscopy. Endoscopy. 2007;39:E347–8.
Yamamoto H, Sekine Y, Sato Y, et al. Total enteroscopy with a nonsurgical steerable double-balloon method. Gastrointest Endosc. 2001;53:216–20.
Matsumoto T, Nakamura S, Esaki M, et al. Double-balloon endoscopy depicts diminutive small bowel lesions in gastrointestinal lymphoma. Dig Dis Sci. 2010;55:158–65.
Kodama T, Ohshima K, Nomura K, et al. Lymphomatous polyposis of the gastrointestinal tract, including mantle cell lymphoma, follicular lymphoma and mucosa-associated lymphoid tissue lymphoma. Histopathology. 2005;47:467–78.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest:
Shunichi Yanai, Shotaro Nakamura, Satoko Yamaguchi, Keisuke Kawasaki, Kazuyuki Ishida, Tamotsu Sugai, Junji Umeno, Motohiro Esaki and Takayuki Matsumoto declare that they have no conflicts of interest.
Human/animal rights:
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institution and national) and with the Helsinki Declaration.
Informed consent:
Informed consent was obtained from the patients for being included in this study.
Rights and permissions
About this article
Cite this article
Yanai, S., Nakamura, S., Yamaguchi, S. et al. Gastrointestinal mantle cell lymphoma with isolated mass and multiple lymphomatous polyposis: report of two cases. Clin J Gastroenterol 10, 327–330 (2017). https://doi.org/10.1007/s12328-017-0740-5
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12328-017-0740-5