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Drug-induced liver injury with autoimmune features complicated with hemophagocytic syndrome

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Abstract

A 60-year-old woman was admitted to our hospital with non-coma acute liver failure. Based on a 1-month history of supplement use, negative viral hepatitis markers, positive antinuclear antibody test, high IgG level, positive HLA-DR4, liver biopsy findings of centrizonal necrosis, and inflammatory cell infiltration in the portal area, she was diagnosed with drug-induced liver injury (DILI) with autoimmune features or the acute hepatitis phase of autoimmune hepatitis (AIH). Although her liver disorder was ameliorated by administration of prednisolone and plasma exchange, anemia and thrombocytopenia were observed during the course of treatment. A bone marrow examination showed hemophagocytosis. Therefore, with no other evidence suggesting infection or malignancy, we determined that the patient had DILI complicated by hemophagocytic syndrome (HPS). Although HPS is very rarely seen in patients with DILI with autoimmune features or the acute hepatitis phase of AIH, this condition should be considered if cytopenia is observed in a patient with DILI.

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Authors and Affiliations

  1. Department of Gastroenterology and Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan

    Manabu Hayashi, Kazumichi Abe, Hiromichi Imaizumi, Ken Okai, Yukiko Kanno, Atsushi Takahashi & Hiromasa Ohira

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  1. Manabu Hayashi
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  2. Kazumichi Abe
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  3. Hiromichi Imaizumi
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  4. Ken Okai
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  5. Yukiko Kanno
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  6. Atsushi Takahashi
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  7. Hiromasa Ohira
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Correspondence to Manabu Hayashi.

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Conflict of Interest:

Manabu Hayashi, Kazumichi Abe, Hiromichi Imaizumi, Ken Okai, Yukiko Kanno, Atsushi Takahashi and Hiromasa Ohira declare that they have no conflict of interest.

Human/Animal Rights:

All procedures followed were in accordance with the Helsinki Declaration of 1975, as revised in 2008(5).

Informed Consent:

Informed consent was obtained from all patients included in the study.

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Hayashi, M., Abe, K., Imaizumi, H. et al. Drug-induced liver injury with autoimmune features complicated with hemophagocytic syndrome. Clin J Gastroenterol 9, 150–155 (2016). https://doi.org/10.1007/s12328-016-0638-7

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  • DOI: https://doi.org/10.1007/s12328-016-0638-7

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