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Efficacy and Safety of Ultrafiltration in Patients with Heart Failure: A Single-Center Experience

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Abstract

Introduction

There is a paucity of literature on the efficacy and safety of ultrafiltration in Chinese patients with heart failure (HF). Therefore, we aimed to compare the efficacy and safety of ultrafiltration with diuretics and provide information and evidence as to the best approach for patients with HF.

Methods

In this single-center, non-randomized interventional study patients with HF either received diuretics or ultrafiltration. The efficacy outcomes included changes in the weight, dyspnea score, and 6-min walk distance from baseline to 48 h after treatment. Safety outcomes were evaluated in both the groups with respect to changes in systolic blood pressure, heart rate, serum creatinine, blood urea nitrogen, blood potassium ion concentration, and blood sodium ion concentration.

Results

A total of 149 patients with HF (diuretics, 73; ultrafiltration, 76) were included. At 48 h, patients in the ultrafiltration group showed significantly greater weight loss and better improvement in dyspnea score and 6-min walk distance compared to patients in the control group (P < 0.05). However, the two groups showed no statistically significant difference in terms of safety outcomes such as systolic blood pressure, heart rate, serum creatinine, blood urea nitrogen, blood potassium ion concentration, and blood sodium ion concentration, suggesting similar safety profiles of both the groups.

Conclusion

Ultrafiltration was associated with greater weight loss and better dyspnea score and 6-min walk distance with similar safety profiles as compared with diuretics. Ultrafiltration can be considered as an optimal option for Chinese patients with HF.

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Acknowledgements

We thank the participants of the study.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors. The authors funded the journal’s Rapid Service Fee.

Author Contributions

Shen Xiangli and Li Lan contributed in the conception and design of the study. Zu Libiya, Ma Jun and Jiang Shubin contributed in data acquisition. Shen Xiangli, Zu Libiya, and Ma Jun analyzed and interpreted the data. Shen Xiangli, Li Lan and Jiang Shubin were involved in drafting and critically critical revision of the manuscript. All authors approved the final version of the manuscript submitted and agree to be accountable for all aspects of the work.

Disclosures

Shen Xiangli, Li Lan, Zu Libiya, Ma Jun, and Jiang Shubin have nothing to disclose.

Compliance with Ethics Guidelines

The study received ethics committee approval from Traditional Chinese Medicine Hospital affiliated to Xinjiang Medical University (Approval no. 2009-226).

Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Heart Center, Traditional Chinese Medicine Affiliated to Xinjiang Medical University, Urumqi, 830000, China

    Shen Xiangli, Li Lan, Zu Libiya, Ma Jun & Jiang Shubin

Authors
  1. Shen Xiangli
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  2. Li Lan
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  3. Zu Libiya
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  4. Ma Jun
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  5. Jiang Shubin
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Corresponding author

Correspondence to Jiang Shubin.

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Xiangli, S., Lan, L., Libiya, Z. et al. Efficacy and Safety of Ultrafiltration in Patients with Heart Failure: A Single-Center Experience. Adv Ther 39, 4523–4532 (2022). https://doi.org/10.1007/s12325-022-02227-w

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  • DOI: https://doi.org/10.1007/s12325-022-02227-w

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