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Survival Outcomes of Lobectomy Versus Segmentectomy in Clinical Stage I Non-Small Cell Lung Cancer: A Meta-Analysis

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Abstract

Introduction

The gold standard surgical therapy for patients with clinical stage I non-small cell lung cancer (NSCLC) is lobectomy with mediastinal lymph node dissection. Meanwhile, segmentectomy has emerged as an alternative choice with the advantage of fewer postoperative complications. The acceptance of this procedure remains controversial, and conflicting results exist in the retrospective trials.

Objectives

The aim of this meta-analysis was to analyze the survival outcomes of lobectomy versus segmentectomy in clinical stage I NSCLC.

Methods

A computerized literature search was done on published trials in PubMed, Embase, and the Cochrane Library to June 2019 to identify clinical trials. Lung cancer-specific survival (LCSS) and overall survival (OS) were measured as outcomes. Statistical analysis was performed in the Meta-analysis Revman 5.3 software.

Results

A systematic literature search was conducted including seven studies. In this meta-analysis, the LCSS and OS in the lobectomy group were linked to a markedly lower trend in comparison to the segmentectomy group without significant statistical difference (P > 0.05), indicating that lobectomy confers an equivalent survival outcome compared with segmentectomy.

Conclusion

No significant differences were found in survival outcomes between lobectomy and segmentectomy. Further large-scale, prospective, randomized trials are needed to explore reasonable surgical treatments for early-stage lung cancer.

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Acknowledgements

Funding

No funding was received for this study. The Journal’s Rapid Service Fee was funded by the authors.

Compliance with Ethics Guidelines

Ethics approval was not required for this meta-analysis.

Authorship

All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Authorship Contributions

Jian Feng and Li-Feng Wang have made substantial contributions to conception and design of the study, written the manuscript; Ting-Yue Han and Yue Wan searched literature, extracted data from the collected literature and analysed the data; Bing-Hui Chen revised the manuscript; All authors approved the final version of the manuscript.

Disclosures

Jian Feng, Li-Feng Wang, Ting-Yue Han, Yue Wang, Xiu-Yu Wu, Feng Lv, Yang Liu and Bing-Hui Chen have nothing to disclose.

Data Availability

The datasets generated and analyzed during the current study are available from the corresponding author on reasonable request.

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Author notes

    Authors and Affiliations

    1. Department of Thoracic Surgery, Funing People’s Hospital, No. 111 Fcheng Street Road, Funing County, Yancheng City, 224400, Jiangsu Province, China

      Jian Feng, Ting-Yue Han, Yue Wang, Xiu-Yu Wu, Feng Lv, Yang Liu & Bing-Hui Chen

    2. Department of Pathology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, China

      Li-Feng Wang

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    1. Jian Feng
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    Correspondence to Bing-Hui Chen.

    Additional information

    Jian Feng, Li-Feng Wang, Ting-Yue Han contributed equally to this paper.

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    Feng, J., Wang, LF., Han, TY. et al. Survival Outcomes of Lobectomy Versus Segmentectomy in Clinical Stage I Non-Small Cell Lung Cancer: A Meta-Analysis. Adv Ther 38, 4130–4137 (2021). https://doi.org/10.1007/s12325-021-01793-9

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    • DOI: https://doi.org/10.1007/s12325-021-01793-9

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