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Biochemical Significance of miR-155 and miR-375 as Diagnostic Biomarkers and Their Correlation with the NF-κβ/TNF-α Axis in Breast Cancer

  • ORIGINAL RESEARCH ARTICLE
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Abstract

Serum microRNAs (miRs) have recently been proposed as potential cancer biomarkers for early detection. Thyroid hormones play a crucial role in human health, and their alterations are linked to a range of diseases, such as breast cancer. The relationship between NF-κβ, TNF-α, and non-coding RNAs is an urgent need for clinical trials. This study aimed to investigate serum expression folds of miR-155 and miR-375 and their correlations with NF-κβ and TNF-α in breast cancer patients. The current study was conducted on 183 unrelated female participants. Serum levels of free T3 and T4, as well as expression folds of miR-155 and miR-375, were significantly higher in patients with fibroadenoma and breast cancer, despite TSH being significantly lower. Additionally, the signaling of TNF-alpha and NF-κβ were found to be significantly upregulated in the serum of patients with breast cancer. Up-regulation of miR-155 and miR-375 expression may be diagnostic biomarkers of breast cancer, pointing to the role of NF-κβ and TNF-α expression in miR-155 and miR-375 expression as therapeutic targets of breast cancer in the future.

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The authors declare that no funding for the research received.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Science, Beni-Suef University, Salah Salim St., Beni-Suef, 62511, Egypt

    Sahar A. Abdel-Samed, Walaa G. Hozyen & Nabil A. Hasona

  2. Department of Oncology, Faculty of Medicine, Beni-Suef University, Beni Suef, Egypt

    Saeed M. Shaaban

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  1. Sahar A. Abdel-Samed
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  2. Walaa G. Hozyen
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  3. Saeed M. Shaaban
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  4. Nabil A. Hasona
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Correspondence to Nabil A. Hasona.

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Our study was conducted in compliance with the Declaration of Helsinki, and the Research Ethical Committee, Faculty of Medicine, University of Beni-Suef, Egypt provided its approval (FMBSUREC/10042022)".

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Abdel-Samed, S.A., Hozyen, W.G., Shaaban, S.M. et al. Biochemical Significance of miR-155 and miR-375 as Diagnostic Biomarkers and Their Correlation with the NF-κβ/TNF-α Axis in Breast Cancer. Ind J Clin Biochem 39, 226–232 (2024). https://doi.org/10.1007/s12291-022-01101-4

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  • DOI: https://doi.org/10.1007/s12291-022-01101-4

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