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Evaluation of Different Methods for the Detection of Anti- Thyroglobulin Autoantibody: Prevalence of Anti-Thyroglobulin Autoantibody and Anti-Microsomal Autoantibody in Thyroid Cancer Patients

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Abstract

Four anti-thyroglobulin autoantibodies (TgAb) assays were evaluated for their reference interval, method agreement, concordance etc. Prevalence of TgAb and anti-thyroid peroxidase was studied in differentiated thyroid cancer (DTC) and control. Reference intervals for TgAb assays varied from method to method due to varied assay designs. For TgAb correlation coefficients ranged from 0.74 to 0.99 whereas concordance ranged from 81 to 96.1%. Prevalence of thyroid antibodies mainly TgAb was increased in DTC primarily in females. Use of sensitive immunoassays is recommended for thyroid autoantibody measurement. Diagnosis and follow-up are difficult in DTC with coexisting thyroid autoimmunity. Hence, careful monitoring with regular surveillance is suggested.

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Authors and Affiliations

  1. Radiation Medicine Centre, BARC, TMH Annexe, Parel, Mumbai, 400 012, India

    Chandrakala Gholve, Archana Damle, Savita Kulkarni, Sharmila Banerjee & MGR. Rajan

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  1. Chandrakala Gholve
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  2. Archana Damle
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  3. Savita Kulkarni
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  4. Sharmila Banerjee
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  5. MGR. Rajan
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Correspondence to Savita Kulkarni.

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Gholve, C., Damle, A., Kulkarni, S. et al. Evaluation of Different Methods for the Detection of Anti- Thyroglobulin Autoantibody: Prevalence of Anti-Thyroglobulin Autoantibody and Anti-Microsomal Autoantibody in Thyroid Cancer Patients. Ind J Clin Biochem 37, 473–479 (2022). https://doi.org/10.1007/s12291-021-01005-9

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  • DOI: https://doi.org/10.1007/s12291-021-01005-9

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