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To Evaluate Platelet Indices, Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio as Prognostic and Risk Factors in Patients with Coronary Artery Disease

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Abstract

To evaluate platelet indices, platelet to lymphocyte ratio and neutrophil to lymphocyte ratio as prognostic and risk factors in patients with coronary artery disease Introduction: cardiovascular diseases have 12 million deaths annually which is one of the commonest causes of death globally. Platelet parameters like Mean platelet volume (MPV), platelet distribution width (PDW) and WBC parameters like Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio(PLR) have recently been emerging as a new prognostic marker in number of coronary artery disease (CAD) with limited studies to explore their utility. Aims and objectives: this study aimed to evaluate MPV, P-LCR, PDW, PLR, NLR and GRACE risk score in CAD patients. Material and methods: this descriptive cross-sectional study was done in 330 cases of CAD and 200 healthy controls were studied.MPV, platelet-large cell ratio (P-LCR), PLR, NLR and PDW of patients were analyzed. Results: In our study, 245 were males and 85 were females. Mean PDW, MPV, Mean PLCR, Mean NLR was significantly higher in CAD cases as compared to controls (p value < 0.05). Mean PLR was not significantly different in CAD cases and controls. MPV was more associated risk predictor of CAD (8.98 times) followed by NLR (2.79 times), PDW (1.53 times) and PLCR (1.02 times). Discussion and conclusion: platelet indices, NLR and PLR are simple cost effective parameters and in future these might be useful adjuvant tests in conjunction with conventional biochemical cardiac markers in early prediction of risk of CAD in patients admitted to hospital and can guide clinicians in assessing the prognosis on short and long term follow up of these patients in terms of morbidity and mortality.

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Authors and Affiliations

  1. Department of Laboratory Sciences & Molecular Medicine, Army Hospital (R& R), Delhi Cantt, New Delhi, 110010, Delhi, India

    Pradeep Venkataswamy Reddy, Ankur Ahuja, Bhushan Asthana, Kanwaljeet Singh & Gurpreet Sagoo

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  1. Pradeep Venkataswamy Reddy
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  2. Ankur Ahuja
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  3. Bhushan Asthana
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  4. Kanwaljeet Singh
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Contributions

Concepts: PV, AA, BA, KS, GS; Design: KS, GS; Definition of intellectual content: PV, AA, BA, KS, GS; Literature search:PV, AA,, KS, GS; Data acquisition, PV, BA, KS, GS; Data analysis: AA, KS; Statistical analysis: PV; Manuscript preparation: PV, AA, KS; Manuscript editing: AA, KS; Manuscript review: BA, KS, GS; Guarantor: PV.

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Correspondence to Kanwaljeet Singh.

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Venkataswamy Reddy, P., Ahuja, A., Asthana, B. et al. To Evaluate Platelet Indices, Platelet to Lymphocyte Ratio and Neutrophil to Lymphocyte Ratio as Prognostic and Risk Factors in Patients with Coronary Artery Disease. Indian J Hematol Blood Transfus 40, 103–107 (2024). https://doi.org/10.1007/s12288-023-01664-z

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