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Splenic Lymphomas: A Tertiary Care Center Experience and Review of Literature

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Abstract

Primary splenic lymphomas are rare with the majority of lymphomas in spleen being secondary to an extra-splenic lymphoma. We aimed to analyze the epidemiological profile of the splenic lymphoma and review the literature. This was a retrospective study including all splenectomies and splenic biopsies from 2015 to September 2021. All the cases were retrieved from Department of Pathology. Detailed histopathological, clinical and demographic evaluation was done. All the lymphomas were classified according to WHO 2016 classification. A total of 714 splenectomies were performed for a variety of benign causes, as part of tumor resections and for the diagnosis of lymphoma. Few core biopsies were also included. A total of 33 lymphomas diagnosed in the spleen, primary splenic lymphomas constituted 84.84% (n = 28) of the cohort with 5 (15.15%) having the primary site elsewhere. The primary splenic lymphomas constituted 0.28% of all the lymphomas arising at various sites. Adult population (19–65 years) formed the bulk (78.78%) with a slight male preponderance. Splenic marginal zone lymphomas (n = 15, 45.45%) comprised of major proportion of cases followed by primary splenic diffuse large B-cell lymphoma (n = 4, 12.12%). Splenectomy was the main course of treatment for SMZL with a good overall outcome, with chemotherapy ± radiotherapy forming the mainstay in other lymphomas. Lymphomas in spleen can be infiltrative or a primary, hence proper clinic-radiological and pathological evaluation is required. Appropriate management is guided by the precise and detailed evaluation by the pathologist, requiring understanding of the same.

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Data Availability

Most of the raw data submitted as tables. For any further clarification the data will be available. The data was presented in SOHO Italy 2020. The abstract published Jain, S., Mallick, S., Ramteke, P., Gogia, A., Agarwal, M., Dass, J., Yadav, R., & Sharma, M. (2020). Pandora box of Lymphomas in Spleen: Session: Non Hodgkin and Hodgkin Lymphomas. Hematology Reports, 12(s1).

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Funding

The data was collected as part of projects- SERB ECR/2015/415, SERB EEQ/2016/402.

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Authors and Affiliations

  1. Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India

    Surabhi Jain, Prashant Ramteke, Trisha Mandal, Mehar Chand Sharma & Saumyaranjan Mallick

  2. Department of Medical Oncology (DR. B.R.A. Institute Rotary Cancer Hospital), All India Institute of Medical Sciences, New Delhi, India

    Ajay Gogia, Raja Parmanik, Sameer Bakhshi & Atul Sharma

  3. Department of Hematology, All India Institute of Medical Sciences, New Delhi, India

    Mukul Aggarwal, Jasmita Dass & Manoranjan Mahapatra

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  1. Surabhi Jain
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Contributions

Concept: SM, Data Collection: SJ, PR, TM. Manuscript writing: SJ, PR Clinical Information: AG, MA, MM, RP, SB. AS. Manuscript review: SM, JD, MCS. Final Review–SM.

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Correspondence to Saumyaranjan Mallick.

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Jain, S., Ramteke, P., Gogia, A. et al. Splenic Lymphomas: A Tertiary Care Center Experience and Review of Literature. Indian J Hematol Blood Transfus 39, 402–412 (2023). https://doi.org/10.1007/s12288-022-01621-2

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