Skip to main content

Advertisement

SpringerLink
Log in

Comparison of Clinical Features Between Primary and Secondary Breast Diffuse Large B Cell Lymphoma: A Yokohama Cooperative Study Group for Hematology Multicenter Retrospective Study

  • Original Article
  • Published:
Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

We performed a retrospective analysis of DLBCL with breast involvement to compare the prognosis of primary breast lymphoma (PBL) to secondary breast lymphoma (SBL; especially in limited stage cases). We retrospectively reviewed records of 25 diffuse large B-cell lymphoma (DLBCL) patients with breast involvement who received chemotherapy between January 2000 and August 2012. We compared clinical features and prognosis among patients with PBL (n = 11), limited stage SBL (LSBL; n = 6), and advanced stage SBL (ASBL, n = 8). The PBL group had significantly lesser patients with breast tumours (BTs) > 5 cm than the SBL group (P = 0.02). After a median follow-up of 71.3 months, we observed significantly better 5-year overall survival (OS) in the PBL group (90.0%) than in the LSBL (33.3%, P = 0.01) group, but not for progression-free survival (PFS). Patients with BT > 5 cm had worse OS (P = 0.01) and PFS (P = 0.04) than those with BT ≤ 5 cm. PBL had a better prognosis than SBL among limited stage DLBCL.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Aviv A, Tadmor T, Polliack A (2013) Primary diffuse large B-cell lymphoma of the breast: looking at pathogenesis, clinical issues and therapeutic options. Ann Oncol 24(9):2236–2244

    Article  CAS  Google Scholar 

  2. Cheah CY, Campbell BA, Seymour JF (2014) Primary breast lymphoma. Cancer Treat Rev 40(8):900–908

    Article  Google Scholar 

  3. Tomita N, Yokoyama M, Yamamoto W, Watanabe R, Shimazu Y, Masaki Y et al (2012) Central nervous system event in patients with diffuse large B-cell lymphoma in the rituximab era. Cancer Sci 103(2):245–251

    Article  CAS  Google Scholar 

  4. Talwalkar SS, Miranda RN, Valbuena JR, Routbort MJ, Martin AW, Medeiros LJ (2008) Lymphomas involving the breast: a study of 106 cases comparing localized and disseminated neoplasms. Am J Surg Pathol 32(9):1299–1309

    Article  Google Scholar 

  5. Wiseman C, Liao KT (1972) Primary lymphoma of the breast. Cancer 29(6):1705–1712

    Article  CAS  Google Scholar 

  6. Ryan G, Martinelli G, Kuper-Hommel M, Tsang R, Pruneri G, Yuen K et al (2008) Primary diffuse large B-cell lymphoma of the breast: prognostic factors and outcomes of a study by the International Extranodal Lymphoma Study Group. Ann Oncol 19(2):233–241

    Article  CAS  Google Scholar 

  7. Jia Y, Sun C, Liu Z, Wang W, Zhou X (2018) Primary breast diffuse large B-cell lymphoma: a population-based study from 1975 to 2014. Oncotarget. 9(3):3956–3967

    Article  Google Scholar 

  8. Lin YC, Tsai CH, Wu JS, Huang CS, Kuo SH, Lin CW et al (2009) Clinicopathologic features and treatment outcome of non-Hodgkin lymphoma of the breast—a review of 42 primary and secondary cases in Taiwanese patients. Leuk Lymphoma 50(6):918–924

    Article  CAS  Google Scholar 

  9. Kanda Y (2013) Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transplant 48(3):452–458

    Article  CAS  Google Scholar 

  10. Fukuhara S, Watanabe T, Munakata W, Mori M, Maruyama D, Kim SW et al (2011) Bulky disease has an impact on outcomes in primary diffuse large B-cell lymphoma of the breast: a retrospective analysis at a single institution. Eur J Haematol 87(5):434–440

    Article  Google Scholar 

  11. Avilés A, Delgado S, Nambo MJ, Neri N, Murillo E, Cleto S (2005) Primary breast lymphoma: results of a controlled clinical trial. Oncology. 69(3):256–260

    Article  Google Scholar 

  12. Niitsu N, Okamoto M, Nakamine H, Hirano M (2008) Clinicopathologic features and treatment outcome of primary breast diffuse large B-cell lymphoma. Leuk Res 32(12):1837–1841

    Article  Google Scholar 

  13. Ludmir EB, Milgrom SA, Pinnix CC, Gunther JR, Westin J, Oki Y et al (2018) Primary breast diffuse large B-cell lymphoma: treatment strategies and patterns of failure. Leuk Lymphoma 59(12):2896–2903

    Article  Google Scholar 

  14. Hu S, Song Y, Sun X, Su L, Zhang W, Jia J et al (2018) Primary breast diffuse large B-cell lymphoma in the rituximab era: therapeutic strategies and patterns of failure. Cancer Sci 109(12):3943–3952

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We would like to thank Editage (https://www.editage.jp) for English language editing.

Author information

Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Kanagawa Cancer Center, 2-3-2, Nakao, Asahi-ward, Yokohama, 241-8515, Kanagawa, Japan

    Hiroyuki Takahashi, Rika Sakai, Takayuki Sakuma & Ayako Matsumura

  2. Department of Hematology, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan

    Kazuho Miyashita, Yoshimi Ishii, Yuki Nakajima & Ayumi Numata

  3. Department of Hematology/Oncology, Yamato Municipal Hospital, Yamato, Kanagawa, Japan

    Yukako Hattori & Chizuko Hashimoto

  4. Department of Hematology and Clinical Immunology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan

    Takuya Miyazaki & Hideaki Nakajima

  5. Department of Hematology, Shizuoka Red Cross Hospital, Shizuoka, Japan

    Hideyuki Koharazawa & Jun Taguchi

  6. Department of Internal Medicine, Yokohama Ekisakai Hospital, Yokohama, Kanagawa, Japan

    Sachiya Takemura

  7. Department of Hematology, Fujisawa City Hospital, Fujisawa, Kanagawa, Japan

    Katsumichi Fujimaki

  8. Department of Hematology, Saiseikai Yokohama Nanbu Hospital, Yokohama, Kanagawa, Japan

    Hiroyuki Fujita

Authors
  1. Hiroyuki Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rika Sakai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takayuki Sakuma
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ayako Matsumura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kazuho Miyashita
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yoshimi Ishii
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yuki Nakajima
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ayumi Numata
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yukako Hattori
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Takuya Miyazaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Chizuko Hashimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Hideyuki Koharazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Sachiya Takemura
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Jun Taguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Katsumichi Fujimaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Hiroyuki Fujita
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Hideaki Nakajima
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hiroyuki Takahashi.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Takahashi, H., Sakai, R., Sakuma, T. et al. Comparison of Clinical Features Between Primary and Secondary Breast Diffuse Large B Cell Lymphoma: A Yokohama Cooperative Study Group for Hematology Multicenter Retrospective Study. Indian J Hematol Blood Transfus 37, 60–66 (2021). https://doi.org/10.1007/s12288-020-01307-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12288-020-01307-7

Keywords

Search

Navigation