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Relationship between MRI findings and invasive breast cancer with podoplanin-positive cancer-associated fibroblasts

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Abstract

Objective

Purpose of our study is to assess the relationship between MRI findings and invasive breast cancer (IBC) with cancer-associated fibroblasts (CAFs) that are positive for podoplanin.

Methods

We retrospectively analyzed the consecutive 109 IBCs. The IBCs were dichotomized as with (+) or without (−) podoplanin-positive CAFs. In MRI analyses, the dichotomized IBCs were compared the lesion to muscle ratio (L/M ratio) in STIR images, the ADC value, the distribution of kinetic parameters, and morphological findings.

Results

Of the 109 IBCs, 28 (26%) IBCs had podoplanin(+) CAFs. Compared to the podoplanin(−) group, the podoplanin(+) group tended to have a more malignant pathological status. In the STIR images, the podoplanin(+) group had significantly higher L/M ratio (7.59 vs. 6.55, p = 0.040). In a dynamic study, the podoplanin(+) group had a significantly higher percentage of the washout pattern (42.21% vs. 29.43%, p = 0.045). There were 23 mass lesions and 5 non-mass enhancement (NME) lesions in the podoplanin(+) group, and 69 mass lesions and 12 NME lesions in the podoplanin(−) group. The mass lesions of the podoplanin(−) group had a significantly higher likelihood of showing an irregular shape (n = 47 vs. 8, p = 0.035). The podoplanin(+) group’s lesions had a significantly higher likelihood of showing a circumscribed margin (n = 14 vs. 6, p < 0.001) and a rim enhancement (n = 10 vs. 13, p = 0.047). In multivariate analyses, only high nuclear grade was significant predictive value of podoplanin(+) CAFs.

Conclusion

Although not significant in multivariate analyses, MRI findings may be used to determine the podoplanin-positive CAF status of invasive breast cancer.

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Funding

The authors state that this work has not received any funding.

Author information

Authors and Affiliations

  1. Department of Radiology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501, Japan

    Ken Yamaguchi, Takahiko Nakazono, Ryoko Egashira, Takeshi Imaizumi & Hiroyuki Irie

  2. Department of Radiology, Saga Central Hospital, 3-8-1 Hyogominami, Saga, 849-8522, Japan

    Yukiko Hara & Isao Kitano

  3. Ajisai Clinic, 1-9-38 Ekimaechuo, Saga, 840-0801, Japan

    Takahiro Hamamoto

  4. Department of Surgery, Saga Central Hospital, 3-8-1 Hyogominami, Saga, 849-8522, Japan

    Kazumitsu Kiyomatsu

  5. Department of Pathology, Saga Central Hospital, 3-8-1 Hyogominami, Saga, 849-8522, Japan

    Fumio Yamasaki

  6. Department of Pathology and Laboratory Medicine, Kurume University Medical Center, 155-1 Kokubu, Kurume, 859-0863, Japan

    Rin Yamaguchi

Authors
  1. Ken Yamaguchi
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  2. Yukiko Hara
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  3. Isao Kitano
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  4. Takahiro Hamamoto
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  8. Takahiko Nakazono
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  9. Ryoko Egashira
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  10. Takeshi Imaizumi
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  11. Hiroyuki Irie
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Contributions

Guarantor of integrity of the entire study: KY; Study concept and design: KY; Literature research: KY; Clinical studies: YH, IK, TH, KK, FY, RY; Experimental studies/data analysis: KY, YH, FY, RE, RY; Statistical analysis: KY, TI; Manuscript preparation: KY; Manuscript editing: TN, HI.

Corresponding author

Correspondence to Ken Yamaguchi.

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Conflict of interest

Dr. Egashira reports personal fees from Shionogi, personal fees from Boehringer Ingelheim Japan, personal fees from Bayer Japan, personal fees from AstraZeneca, outside the submitted work. All the other authors declared that they have no conflict of interest.

Ethical approval

This study was approved by the Ethics Committee of the Saga Central Hospital. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

This retrospective study was approved by the Institutional Review Board of the Saga Central Hospital, and written informed consent was waived.

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Yamaguchi, K., Hara, Y., Kitano, I. et al. Relationship between MRI findings and invasive breast cancer with podoplanin-positive cancer-associated fibroblasts. Breast Cancer 28, 572–580 (2021). https://doi.org/10.1007/s12282-020-01198-6

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  • DOI: https://doi.org/10.1007/s12282-020-01198-6

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