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Peritoneal cancer arising after total abdominal hysterectomy and bilateral salpingo-oophorectomy for cervical cancer in a patient with right breast cancer and germline mutation of BRCA1 gene: a case report and literature review

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Abstract

Primary peritoneal carcinoma is usually advanced at diagnosis and curability is low unless the patient has a small tumor burden. Peritoneal carcinoma can occur in association with hereditary breast and ovarian cancer syndrome, which is thought to account for 5–6% of all breast cancer. Mutations of two breast cancer susceptibility genes, BRCA1 and BRCA2, are responsible for hereditary breast and ovarian cancer. Women with BRCA1/2 mutations often undergo risk-reducing salpingo-oophorectomy (RRSO) to prevent both ovarian and breast cancer. However, peritoneal carcinoma has been reported to develop after RRSO in patients with BRCA1/2 mutations. We experienced a patient with peritoneal carcinoma and inguinal lymph node metastasis after surgical resection of breast cancer and subsequent RRSO. This report describes the first case of peritoneal carcinoma arising after RRSO in a Japanese patient with BRCA1 mutation, including a review of the literature on peritoneal carcinoma associated with BRCA1/2 mutation.

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Abbreviations

BO:

Bilateral oophorectomy

HBOC:

Hereditary breast and ovarian cancer

RRSO:

Risk-reducing salpingo-oophorectomy

PPC:

Primary peritoneal carcinoma

PSCP:

Papillary serous carcinoma of the peritoneum

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Acknowledgements

This study was partially supported by “April Bride” Memorial Research Grant from the Foundation for Promotion of Cancer Research. “April Bride” is a Japanese movie of a story of young woman with breast cancer based on a documentary TV program in 2009.

Author information

Authors and Affiliations

  1. Department of Surgery, Tochigi Cancer Center, Yohnan 4-9-13, Utsunomiya, Tochigi, 320-0834, Japan

    Michiko Harao & Jiro Ando

  2. Department of Gynecology, Tochigi Cancer Center, Yohnan 4-9-13, Utsunomiya, Tochigi, 320-0834, Japan

    Hiroyuki Kamata

  3. Department of Pathology, Tochigi Cancer Center, Yohnan 4-9-13, Utsunomiya, Tochigi, 320-0834, Japan

    Nobuo Hoshi & Seiji Igarashi

  4. Department of Diagnostic Radiology, Tochigi Cancer Center Hospital, Yohnan 4-9-13, Utsunomiya, Tochigi, 320-0834, Japan

    Ryuzo Sekiguchi

  5. Clinic of Cancer Prevention and Genetic Counseling, Tochigi Cancer Center, Yohnan 4-9-13, Utsunomiya, Tochigi, 320-0834, Japan

    Kokichi Sugano

  6. Oncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute, Yohnan 4-9-13, Utsunomiya, Tochigi, 320-0834, Japan

    Kokichi Sugano

Authors
  1. Michiko Harao
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  2. Jiro Ando
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  3. Hiroyuki Kamata
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  4. Nobuo Hoshi
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  5. Seiji Igarashi
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  6. Ryuzo Sekiguchi
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  7. Kokichi Sugano
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Corresponding author

Correspondence to Kokichi Sugano.

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Harao, M., Ando, J., Kamata, H. et al. Peritoneal cancer arising after total abdominal hysterectomy and bilateral salpingo-oophorectomy for cervical cancer in a patient with right breast cancer and germline mutation of BRCA1 gene: a case report and literature review. Breast Cancer 25, 243–249 (2018). https://doi.org/10.1007/s12282-017-0813-9

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  • DOI: https://doi.org/10.1007/s12282-017-0813-9

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