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Impact of young age on local control after partial breast irradiation in Japanese patients with early stage breast cancer

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Abstract

Background

Partial breast irradiation (PBI) is an alternative to whole breast irradiation (WBI) for breast-conserving therapy (BCT). A randomised phase 3 trial demonstrated that PBI using multicatheter brachytherapy had an equivalent rate of local recurrence, disease-free survival, and overall survival as compared to WBI. However, limited data are available on PBI efficacy for young patients with breast cancer.

Methods

We evaluated consecutive patients with Tis-2 (≤ 3 cm) N0-1 breast cancer who underwent BCT. For PBI, patients received radiotherapy using multicatheter brachytherapy in an accelerated manner with a dose of 32 Gy in eight fractions over 5–6 days. For WBI, patients received an external beam radiation therapy that was applied to the entire breast with a total dose of 50 Gy in fractions of 2 Gy for 5 weeks. Two hundred seventy-four patients with 278 lesions received PBI; 190 patients with 193 lesions received WBI.

Results

Patients aged <50 years including 98 women with 99 lesions receiving PBI and 85 women with 85 lesions receiving WBI were selected. Ipsilateral breast tumor recurrence rate was 3.0 and 2.4 % by PBI and WBI, respectively (P = 0.99). There was no significant difference in 4-year probability of disease-free survival (97.6 and 91.4 % for PBI and WBI, respectively; P = 0.87).

Conclusions

This is the first report of PBI efficacy in young patients in Asia. Although it is a nonrandomized retrospective chart review of a small cohort of patients with a relatively short follow-up period, PBI may be a better option than WBI following BCS in some young patients with breast cancer.

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Acknowledgments

The authors would like to thank Enago (http://www.enago.jp) for the English language review.

Author information

Authors and Affiliations

  1. Department of Breast Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo, 196-0003, Japan

    Kazuhiko Sato, Yoshio Mizuno, Hiromi Fuchikami & Naoko Takeda

  2. Department of Radiation Oncology, Tokyo-West Tokushukai Hospital, 3-1-1 Matsubara, Akishima, Tokyo, 196-0003, Japan

    Masahiro Kato, Takahiro Shimo & Jun Kubota

  3. Inoue Ladies Clinic, 1-26-9 Fujimi, Tachikawa, Tokyo, 190-0013, Japan

    Naoko Takeda & Yuko Inoue

  4. Seto Hospital, 8-6 Kanayama, Tokorozawa, Saitama, 359-1128, Japan

    Hiroshi Seto

  5. Health Evaluation Center, Utsunomiya Memorial Hospital, 1-3-16 Odori, Utsunomiya, Tochigi, 320-0811, Japan

    Tomohiko Okawa

Authors
  1. Kazuhiko Sato
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  2. Yoshio Mizuno
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  3. Hiromi Fuchikami
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  4. Masahiro Kato
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  6. Jun Kubota
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  8. Yuko Inoue
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  9. Hiroshi Seto
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  10. Tomohiko Okawa
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Correspondence to Kazuhiko Sato.

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Sato, K., Mizuno, Y., Fuchikami, H. et al. Impact of young age on local control after partial breast irradiation in Japanese patients with early stage breast cancer. Breast Cancer 24, 79–85 (2017). https://doi.org/10.1007/s12282-016-0669-4

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  • DOI: https://doi.org/10.1007/s12282-016-0669-4

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