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Onychomycosis Caused by Fusarium Species: a Review

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Abstract

Purpose of Review

The purpose of this review is to provide a comprehensive analysis of Fusarium onychomycosis, a fungal infection affecting the nails caused by various species of the genus Fusarium. The review aims to explore the etiology, epidemiology, pathogenesis, clinical features, diagnosis, treatment, and future perspectives of Fusarium onychomycosis.

Recent Findings

Recent research has shed light on the taxonomy and different species of Fusarium implicated in onychomycosis, as well as the environmental sources and routes of infection. Advancements in laboratory diagnostic techniques, including molecular methods, have improved the accuracy of diagnosis. Furthermore, the review highlights the challenges associated with treatment, such as antifungal resistance, and discusses emerging treatment modalities and preventive measures.

Summary

Onychomycosis caused by Fusarium species presents unique challenges in diagnosis and treatment. It is prevalent in certain regions and associated with specific risk factors. Proper identification of the causative agent and consideration of patient comorbidities are crucial for effective treatment. While antifungal therapy remains the mainstay, combination approaches and emerging treatments hold promise for improving clinical outcomes. Further research is needed to enhance our understanding of Fusarium onychomycosis and develop more effective therapeutic strategies.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Lipner SR, Scher RK. Part I: onychomycosis: clinical overview and diagnosis. J Am Acad Dermatol. 2019;80(4):835–51. https://doi.org/10.1016/j.jaad.2018.03.062.

    Article  PubMed  Google Scholar 

  2. Gupta AK, Stec N, Summerbell RC, Shear NH, Piguet V, Tosti A, Piraccini BM. Onychomycosis: a review. J Eur Acad Dermatol Venereol. 2020;34(9):1972–90. https://doi.org/10.1111/jdv.16394.

    Article  CAS  PubMed  Google Scholar 

  3. Uriarte-Mayorga DF, Gómez-González BA, Armenta-Ramos JS, et al. Onicomicosis por Fusarium Sp.: una entidad clínica rara A propósito de un caso. Med Cutan Iber Lat Am. 2018;46(2):142–5.

    Google Scholar 

  4. Ranawaka RR, Nagahawatte A, Gunasekara TA. Fusarium onychomycosis: prevalence, clinical presentations, response to itraconazole and terbinafine pulse therapy, and 1-year follow-up in nine cases. Int J Dermatol. 2015;54(11):1275–82. https://doi.org/10.1111/ijd.12906.

    Article  CAS  PubMed  Google Scholar 

  5. Uemura EVG, Barbosa MDS, Simionatto S, Al-Harrasi A, Al-Hatmi AMS, Rossato L. Onychomycosis caused by Fusarium species. J Fungi (Basel). 2022;8(4):360. https://doi.org/10.3390/jof8040360.

    Article  PubMed  Google Scholar 

  6. Araiza J, Saldaña M, Dávila I, Tirado-Sánchez A. Onicomicosis por Fusarium spp en pacientes con neoplasias hematológicas. Dermatol Rev Mex. 2020;64(4):371–8.

    Google Scholar 

  7. Phaitoonwattanakij S, Leeyaphan C, Lertrujiwanit K, Bunyaratavej S. Predisposing factors, clinical features and treatment outcomes of Fusarium onychomycosis and comparison of its characteristics with Neoscytalidium onychomycosis. J Mycol Med. 2021;31(3):101165. https://doi.org/10.1016/j.mycmed.2021.

    Article  PubMed  Google Scholar 

  8. Nucci M, Barreiros G, Akiti T, Anaissie E, Nouér SA. Invasive fusariosis in patients with hematologic diseases. J Fungi (Basel). 2021;7(10):815. https://doi.org/10.3390/jof7100815.

    Article  CAS  PubMed  Google Scholar 

  9. Castro López N, Casas C, Sopo L, Rojas A, Del Portillo P, Cepero de García MC, Restrepo S. Fusarium species detected in onychomycosis in Colombia. Mycoses. 2009;52(4):350–6. https://doi.org/10.1111/j.1439-0507.2008.01619.x.

    Article  PubMed  Google Scholar 

  10. Varon AG, Nouer SA, Barreiros G, Trope BM, Magalhães F, Akiti T, Garnica M, Nucci M. Superficial skin lesions positive for Fusarium are associated with subsequent development of invasive fusariosis. J Infect. 2014;68(1):85–9. https://doi.org/10.1016/j.jinf.2013.08.011.

    Article  PubMed  Google Scholar 

  11. Estrada VFM, González AZ, Lugo FP. Onicomicosis por Fusarium chlamydosporum en un paciente diabético Reporte de caso y revisión de la literatura. Dermatología Cosmética, Médica y Quirúrgica. 2022;20(1):33–6.

    Google Scholar 

  12. Sequeira-Oviedo PM, Lozada-Alvarado S, Salas-Campos I, Jaikel-Víquez D. Susceptibilidad antimicrobiana de los aislamientos de Fusarium solani provenientes de onicomicosis. Dermatol Rev Mex. 2017;61(3):197–205.

    Google Scholar 

  13. Tupaki-Sreepurna A, Kindo AJ. Fusarium: the versatile pathogen. Indian J Med Microbiol. 2018;36(1):8–17. https://doi.org/10.4103/ijmm.IJMM_16_24.

    Article  PubMed  Google Scholar 

  14. Van Diepeningen AD, Al-Hatmi AMS, Brankovics B, et al. Taxonomy and clinical spectra of Fusarium species: where do we stand in 2014? Curr Clin Micro Rpt. 2014;1:10–8. https://doi.org/10.1007/s40588-014-0003-x.

    Article  Google Scholar 

  15. • Eiga FF, de Castro-Hoshino LV, Sato F, Baesso ML, Silva S, Negri M, Svidzinski TIE. Characterization of a biofilm formed by Fusarium oxysporum on the human nails. Int J Dermatol. 2022;61(2):191–8. https://doi.org/10.1111/ijd.15747. This study clarifies the fusarial pathogenesis and invasion process.

    Article  CAS  Google Scholar 

  16. Machado Vila TV, Sousa Quintanilha N, Rozental S. Miltefosine is effective against Candida albicans and Fusarium oxysporum nail biofilms in vitro. J Med Microbiol. 2015;64:1436–49. https://doi.org/10.1099/jmm.0.000175.

    Article  CAS  PubMed  Google Scholar 

  17. Ngo TMC, Nu PAT, Cao LC, Ha TNT, Do TBT, Thi GT. A case of onychomycosis caused by a terbinafine-susceptible Fusarium solani in Vietnam. Iran J Microbiol. 2022;14(6):932–6. https://doi.org/10.18502/ijm.v14i6.11269.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Gupta AK, Venkataraman M, Renaud HJ, Summerbell R, Shear NH, Piguet V. A paradigm shift in the treatment and management of onychomycosis. Skin Appendage Disord. 2021;7(5):351–8. https://doi.org/10.1159/000516112.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Hoenigl M, Salmanton-García J, Walsh TJ, Nucci M, Neoh CF, Jenks JD, Lackner M, Sprute R, Al-Hatmi AMS, Bassetti M, Carlesse F, Freiberger T, Koehler P, Lehrnbecher T, Kumar A, Prattes J, Richardson M, Revankar S, Slavin MA, Stemler J, Spiess B, Taj-Aldeen SJ, Warris A, Woo PCY, Young JH, Albus K, Arenz D, Arsic-Arsenijevic V, Bouchara JP, Chinniah TR, Chowdhary A, de Hoog GS, Dimopoulos G, Duarte RF, Hamal P, Meis JF, Mfinanga S, Queiroz-Telles F, Patterson TF, Rahav G, Rogers TR, Rotstein C, Wahyuningsih R, Seidel D, Cornely OA. Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology. Lancet Infect Dis. 2021;21(8):e246-e257. https://doi.org/10.1016/S1473-3099(20)30784-2. Erratum in: Lancet Infect Dis. 21(4):e81.

  20. Lecerf P, Abdy S, Vollono L, Pastushenko I, Richert B, André J. Direct examination, histopathology and fungal culture for the diagnosis of onychomycosis: a retrospective, comparative study on 2245 specimens. Mycoses. 2021;64(2):187–93. https://doi.org/10.1111/myc.13201.

    Article  CAS  PubMed  Google Scholar 

  21. Noguchi H, Matsumoto T, Kimura U, Hiruma M, Kano R, Yaguchi T, Ihn H. Non-dermatophyte mould onychomycosis in Japan. Med Mycol J. 2020;61(2):23–31. https://doi.org/10.3314/mmj.20-00007.

    Article  PubMed  Google Scholar 

  22. Bassiri-Jahromi S, Khaksar AA. Nondermatophytic moulds as a causative agent of onychomycosis in Tehran. Indian J Dermatol. 2010;55(2):140–3. https://doi.org/10.4103/0019-5154.62743.

    Article  PubMed  PubMed Central  Google Scholar 

  23. •• Litaiem N, Mnif E, Zeglaoui F. Dermoscopy of onychomycosis: a systematic review. Dermatol Pract Concept. 2023;13(1):e2023072. https://doi.org/10.5826/dpc.1301a72. This review provides a unifying terminology to describe dermoscopic signs of onychomycosis.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Liu X, Yao Z-Y. Advance in application of dermoscopy for onychomycosis diagnosis. Int J Dermatol Venereol. 2019;2(1):19.

    Google Scholar 

  25. Falotico JM, Lipner SR. Updated perspectives on the diagnosis and management of onychomycosis. Clin Cosmet Investig Dermatol. 2022;15(15):1933–57. https://doi.org/10.3760/cma.j.issn.2096-5540.2019.01.004.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Barzilai A, Greenbaum H, Huszar M, Ikher S, Shemer A, Baum S. the role of histological examination of nail clipping in the diagnosis of onychomycosis. Isr Med Assoc J. 2023;25(2):117–21.

    PubMed  Google Scholar 

  27. AvkanOguz V, Karabicak N, Irmak C, Unek T. Fusarium solani species complex infection treated with posaconazole in a liver transplantation patient; a case report. J Mycol Med. 2023;33(3):101382. https://doi.org/10.1016/j.mycmed.2023.101382.

    Article  Google Scholar 

  28. Nucci M, Anaissie E. Cutaneous infection by Fusarium species in healthy and immunocompromised hosts: implications for diagnosis and management. Clin Infect Dis. 2002;35(8):909–20. https://doi.org/10.1086/342328.

    Article  PubMed  Google Scholar 

  29. Hof H. The medical relevance of Fusarium spp. J Fungi (Basel). 2020;6(3):117. https://doi.org/10.3390/jof6030117.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Micology Department, Instituto Dermatológico de Jalisco “José Barba Rubio”, Avenida del Federalismo 3102, 45190, Atejamac Zapopan, Jalisco, Mexico

    Jorge Arturo Mayorga Rodríguez

  2. Department of Dermatology, Instituto Dermatológico de Jalisco “José Barba Rubio”, Avenida del Federalismo 3102, 45190, Atejamac Zapopan, Jalisco, Mexico

    Julio Roberto Hernández-Juárez & Eduardo Corona-Rodarte

  3. Department of Dermatology and Micology, Hospital Civil de Culiacán, Culiacán, Sinaloa, Mexico

    Víctor Fernando Muñoz-Estrada

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  1. Jorge Arturo Mayorga Rodríguez
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  3. Eduardo Corona-Rodarte
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  4. Víctor Fernando Muñoz-Estrada
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Correspondence to Julio Roberto Hernández-Juárez or Eduardo Corona-Rodarte.

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Rodríguez, J.A.M., Hernández-Juárez, J.R., Corona-Rodarte, E. et al. Onychomycosis Caused by Fusarium Species: a Review. Curr Fungal Infect Rep 17, 233–238 (2023). https://doi.org/10.1007/s12281-023-00472-2

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