Abstract
Three new minor pyrrole alkaloids, 3-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]pentanedioic acid (1), (2R)-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-1-methoxy-1-oxobutanoic acid (2), and methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-4-methylpentanoate (3) were isolated from the fruits of Lycium chinense Miller (Solanaceae), along with the known compound, methyl (2R)-[2-formyl-5-(methoxymethyl)-1H-pyrrol-1-yl]-3-(phenyl)propanoate (4). The structures of 1–4 were elucidated by analysis of their 1D- and 2D-NMR and HRMS data. The absolute configurations of 2–4, possessing a stereogenic center in each structure, were determined by comparison of their experimental electronic circular dichroism (ECD) with those of calculated ECD values.
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This paper (Youn UJ) was supported by [RP-Grant 2010 of Ewha Womans University].
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Youn, U.J., Lee, J.Y., Kil, YS. et al. Identification of new pyrrole alkaloids from the fruits of Lycium chinense . Arch. Pharm. Res. 39, 321–327 (2016). https://doi.org/10.1007/s12272-015-0695-3
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DOI: https://doi.org/10.1007/s12272-015-0695-3