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Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery

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Abstract

The heterologous expression of biosynthetic pathways is an indispensable tool for drug discovery and development from natural products. Streptomyces venezuelae is a promising heterologous host as it offers several attractive advantages, such as rapid growth rate, convenient genetic manipulation, and an abundant supply of common biosynthetic building blocks. In recent decades, several S. venezuelae mutant strains have been constructed and used to facilitate the synthesis and derivatization of diverse natural products. In this review article, we have provided a schematic look at these host strains, which were used to synthesize natural products from genetically engineered biosynthetic gene clusters.

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Acknowledgments

Research in authors’ laboratory has been supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (MISP) (2013R1A2A1A01014230), the Intelligent Synthetic Biology Center of the Global Frontier Project funded by MISP (20110031961), High Value-added Food Technology Development Program, Ministry of Agriculture, Food and Rural Affairs, Republic of Korea, and the National Research Council of Science and Technology through the Degree & Research Center program (DRC-14-3-KBSI).

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  1. Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120-750, Republic of Korea

    Eun Ji Kim, Inho Yang & Yeo Joon Yoon

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Kim, E.J., Yang, I. & Yoon, Y.J. Developing Streptomyces venezuelae as a cell factory for the production of small molecules used in drug discovery. Arch. Pharm. Res. 38, 1606–1616 (2015). https://doi.org/10.1007/s12272-015-0638-z

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