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Synthesis of new diorganodiselenides from organic halides: their antiproliferative effects against human breast cancer MCF-7 cells

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Abstract

A new series of bis(aryl or aralkyl) diselenides 5a–5q was synthesized by selenylation from aryl halide (or aralkyl halide) for development of new anticancer agents. The process involves the reaction of aryl halides (or aralkyl halides) with selenium, hydrazine hydrate under atmospheric pressure in the presence of sodium hydroxide, to afford diorganodiselenides. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Among 17 synthesized compounds for inhibiting the growth of these cell lines, 1,2-bis(chloropyridazinyl) diselenide 5a showed the highest potency. This result suggests the potential anticancer activity of compound 5a.

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Acknowledgments

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (No. 2012050022). We would like to acknowledge Professor Joohee Jung (College of Pharmacy, Duksung Women’s University) for the CCK-8 assays of anti-proliferative activities.

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  1. College of Pharmacy, Duksung Women’s University, Seoul, 132-714, Korea

    Chaewon Kim, Jihee Lee & Myung-Sook Park

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  1. Chaewon Kim
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  2. Jihee Lee
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  3. Myung-Sook Park
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Correspondence to Myung-Sook Park.

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Kim, C., Lee, J. & Park, MS. Synthesis of new diorganodiselenides from organic halides: their antiproliferative effects against human breast cancer MCF-7 cells. Arch. Pharm. Res. 38, 659–665 (2015). https://doi.org/10.1007/s12272-014-0407-4

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  • DOI: https://doi.org/10.1007/s12272-014-0407-4

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