Abstract
Ferroptosis is an oxidative form of necrotic cell death highly relevant for many degenerative diseases and cancer. Ferroptosis is marked by iron-dependent lipid peroxidation and is distinct from other cell death modalities. Glutathione peroxidase 4 is the key ferroptosis player as it efficiently controls lipid peroxidation. Transgenic mice and animal models of disease have shown which cells and tissues are prone to undergo ferroptosis. The discovery of novel ferroptosis inhibitors and inducers thus offers the great potential in the development of innovative drugs to treat yet incurable diseases.
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Marcus Conrad Jahrgang 1970. 1992–1998 Biologiestudium an der Universität Konstanz. 2001 Promotion an der LMU München und am Forschungszentrum für Umwelt und Gesundheit (GSF), München. 2001–2005 Postdoktorand am GSF München. 2005–2009 Gruppenleiter am Helmholtz Zentrum München. 2009–2010 Laborleiter bei der Bayer-Schering AG, Berlin. 2010–2012 Leiter „Transgene Einheit“ am Deutschen Zentrum für Neurodegenerative Erkrankungen, München. Seit 2012 Gruppenleiter am Helmholtz Zentrum München.
Svenja Lorenz Jahrgang 1993. 2011–2017 Bachelor- und Masterstudium Molekulare Biotechnologie an der TU München. Seit 2017 Doktorandin in der Arbeitsgruppe Dr. Marcus Conrad am Helmholtz Zentrum München.
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Lorenz, S., Conrad, M. Ferroptose: Tod durch Eisenabhängige Lipidperoxidation. Biospektrum 25, 614–616 (2019). https://doi.org/10.1007/s12268-019-0209-9
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DOI: https://doi.org/10.1007/s12268-019-0209-9