Skip to main content
Log in

Wie RNA die Genregulation beeinflusst

  • Wissenschaft
  • Nicht-codierende RNA
  • Published:
BIOspektrum Aims and scope

Abstract

The first described non-coding RNAs (ncRNAs), microRNAs, regulate mRNA fate in a post-transcriptional manner. With the advent of modern high-throughput methods many novel classes of ncRNAs were described. In contrast to microRNAs, most of these regulate the transcription process itself and hence are of fundamental biological importance. Work in our laboratory addresses how transcriptional regulation by ncRNAs influences biological processes ranging from regeneration to neuronal plasticity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literatur

  1. Elliott SA, Sánchez Alvarado A (2013) The history and enduring contributions of planarians to the study of animal regeneration. Wiley Interdiscip Rev Dev Biol 2:301–326

    Article  CAS  PubMed  Google Scholar 

  2. Reddien PW, Oviedo NJ, Jennings JR et al. (2005) SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells. Science 310:1327–1330

    Article  CAS  PubMed  Google Scholar 

  3. Czech B, Hannon GJ (2016) One loop to rule them all: the ping-pong cycle and piRNA-guided silencing. Trends Biochem Sci 41:324–337

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Sienski G, Donertas D, Brennecke J (2012) Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression. Cell 151:964–980

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Vourekas A, Alexiou P, Vrettos N et al. (2016) Sequence-dependent but not sequence-specific piRNA adhesion traps mRNAs to the germ plasm. Nature 531:390–394

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. De Santa F, Barozzi I, Mietton F et al. (2010) A large fraction of extragenic RNA pol II transcription sites overlap enhancers. PLoS Biol 8:e1000384

    Article  Google Scholar 

  7. Kim TK, Hemberg M, Gray JM et al. (2010) Widespread transcription at neuronal activity-regulated enhancers. Nature 465:182–187

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Sheng M, Greenberg ME (1990) The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4:477–485

    Article  CAS  PubMed  Google Scholar 

  9. Schaukowitch K, Joo JY, Liu X et al. (2014) Enhancer RNA facilitates NELF release from immediate early genes. Mol Cell 56:29–42

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Smola MJ, Rice GM, Busan S et al. (2015) Selective 2′-hydroxyl acylation analyzed by primer extension and mutational profiling (SHAPE-MaP) for direct, versatile and accurate RNA structure analysis. Nat Protoc 10:1643–1669

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Claus-D. Kuhn.

Additional information

Vladyslava Gorbovytska 20082013 Biochemiestudium (B. Sc.) an der Universität Bielefeld. 20132016 Studium der Biochemie und Molekularen Biologie (M. Sc.) an der Universität Bayreuth. Seit 2016 Doktorandin in der Arbeitsgruppe „Gene regulation by non-coding RNA“ innerhalb des Elitenetzwerks Bayern an der Universität Bayreuth.

Iana Kim 20052011 Biologiestudium (B. Sc. und M. Sc.) an der Universität Woronesch, Russische Föderation. 20112014 Forschungsassistentin an der Russischen Akademie der Wissenschaften in Moskau. Seit 2015 Doktorandin in der Arbeitsgruppe „Gene regulation by non-coding RNA“ innerhalb des Elitenetzwerks Bayern an der Universität Bayreuth.

Claus-D. Kuhn 19992003 Biochemiestudium an den Universitäten Regensburg und Stockholm, Schweden. 20032008 Doktorarbeit am Genzentrum der LMU München in der Arbeitsgruppe von Prof. Dr. P. Cramer. 20082014 Postdoc am Cold Spring Harbor Laboratory, New York, USA, in der Arbeitsgruppe von Prof. Dr. L. Joshua-Tor. Seit 2014 Gruppenleiter innerhalb des Elitenetzwerks Bayern an der Universität Bayreuth.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kim, I., Gorbovytska, V. & Kuhn, CD. Wie RNA die Genregulation beeinflusst. Biospektrum 23, 513–515 (2017). https://doi.org/10.1007/s12268-017-0832-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12268-017-0832-2

Navigation