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Wenn Stränge reißen – Wege der DNA-Doppelstrangbruch-Reparatur

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  • Genomische Stabilität
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Abstract

The most severe DNA-damage is the double-strand break (DSB) which, if not processed correctly, can lead to cell death or cancer. Cells have evolved two fundamentally different DSB repair mechanisms. Homologous recombination repair utilizing a homologous template and non-homologous end joining operating without template and without, or with only minimal, homology requirements. Knowledge of these mechanisms at the molecular levels will advance our understanding of cancer development and will pave the way to new strategies for treating cancer.

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Literatur

  1. Schipler A, Iliakis G (2013) DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice. Nucleic Acids Res 16:7589–7605

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Authors and Affiliations

  1. Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, Hufelandstraße 55, D-45122, Essen, Deutschland

    Lisa Marie Krieger & George Iliakis

Authors
  1. Lisa Marie Krieger
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  2. George Iliakis
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Corresponding author

Correspondence to Lisa Marie Krieger.

Additional information

Lisa Marie Krieger Jahrgang 1989. 2009–2014 Studium der Chemischen Biologie (Bachelor und Master) an der TU Dortmund. Seit 2014 Doktorarbeit am Institut für Medizinische Strahlenbiologie am Universitätsklinikum Essen.

George Iliakis Jahrgang 1953. 1975 Diplom in Physik an der University of Athens, Griechenland. 1978 Promotion an der Universität Frankfurt a. M. 1983–1985 Postdoc an der Cleveland Clinic Foundation, Cleveland, OH, USA. 1985–2001 Associate/Full Professor an der Thomas Jefferson University in Philadelphia, PA, USA; dort von 1996–2001 Direktor der Division of Experimental Radiation Oncology. Seit 2001 Professor und Direktor des Instituts für Medizinische Strahlenbiologie am Universitätsklinikum Essen.

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Krieger, L.M., Iliakis, G. Wenn Stränge reißen – Wege der DNA-Doppelstrangbruch-Reparatur. Biospektrum 23, 502–505 (2017). https://doi.org/10.1007/s12268-017-0829-x

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  • DOI: https://doi.org/10.1007/s12268-017-0829-x

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