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Hydantoinasen – von der präbiotischen Evolution zur Aminosäureproduktion

  • Biotechnologie
  • Industrielle Enzyme
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Abstract

The hydantoinase process is used for the large-scale production of optically pure amino acids, with side chains of semisynthetic penicillins as the most prominent products. The origin as well as the natural function of the eponymous enzymes, however, remains unclear to this day. Here we discuss the way of hydantoinases from prebiotic evolution to directed evolution, spanning some billion years from the origin of life to industrial processes.

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Authors and Affiliations

  1. Institut für Bio- und Lebensmitteltechnik Abteilung II: Technische Biologie, Karlsruher Institut für Technologie (KIT), Engler-Bunte-Ring 3, Geb. 40.19, D-76131, Karlsruhe, Deutschland

    Jens Rudat & Ulrike Engel

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  1. Jens Rudat
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  2. Ulrike Engel
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Correspondence to Jens Rudat.

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Rudat, J., Engel, U. Hydantoinasen – von der präbiotischen Evolution zur Aminosäureproduktion. Biospektrum 23, 98–100 (2017). https://doi.org/10.1007/s12268-017-0770-z

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  • DOI: https://doi.org/10.1007/s12268-017-0770-z

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