Abstract
Recent insights into fundamental aspects of angiogenesis move meta-bolism into the spotlight and highlight the importance of endothelial metabolic adaptation for vascular growth. This notion stems from the realization that endothelial cells (ECs) have to meet the metabolic demands of migration and proliferation when they switch from quiescence to vessel growth. Here we discuss how ECs adapt their metabolism during the angiogenic switch and how the forkhead transcription factor FOXO1 regulates this process.
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Kerstin Wilhelm Jahrgang 1988. 2010–2012 Masterstudium Molekulare Medizin an der Universität Jena. 2012–2016 Promotionsstudium am Max-Planck-Institut für Herzund Lungen forschung, Bad Nauheim.
Michael Potente 1996–2002 Medizinstudium in Frankfurt a. M. und Toronto. 2003–2011 Facharztausbildung Innere Medizin und Kardiologie. 2011–2012 Oberarzt, Universität Frankfurt a. M. Seit 2012 unabhängiger Max-Planck-Nachwuchsgruppenleiter, Max-Planck-Institut für Herz- und Lungenforschung, Bad Nauheim.
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Wilhelm, K., Potente, M. Metabolische Regulation des Blutgefäßwachstums. Biospektrum 22, 597–599 (2016). https://doi.org/10.1007/s12268-016-0735-7
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DOI: https://doi.org/10.1007/s12268-016-0735-7