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Pathobiochemie des Sec61-Komplexes in der ER-Membran

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  • ER-Proteinimport
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Abstract

In human cells, the endoplasmic reticulum (ER) is central to protein biogenesis and Ca2+ homeostasis. Protein biogenesis requires an aqueous polypeptide-conducting channel in the ER membrane, the heterotrimeric Sec61 complex; the Ca2+ homeostasis involves a steep Ca2+ gradient from ER to cytosol. Therefore, gating of the Sec61 channel is regulated by substrates and allosteric effectors. Several human diseases are linked to Sec61 complex and its effectors and were termed Sec61-channelopathies.

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Author information

Authors and Affiliations

  1. Kompetenzzentrum Molekulare Medizin, Universität Des Saarlandes, D-66421, Homburg, Deutschland

    Stefan Schorr, Markus Greiner, Adolfo Cavalié & Richard Zimmermann

Authors
  1. Stefan Schorr
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  2. Markus Greiner
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  3. Adolfo Cavalié
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  4. Richard Zimmermann
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Corresponding author

Correspondence to Richard Zimmermann.

Additional information

Stefan Schorr, Markus Greiner, Adolfo Cavalié und Richard Zimmermann (v. l. n. r.) arbeiten seit 2011 im Rahmen eines gemeinsamen SFB 894- Projekts am Zusammenhang von ER-Proteinimport und Kalziumhomöostase.

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Schorr, S., Greiner, M., Cavalié, A. et al. Pathobiochemie des Sec61-Komplexes in der ER-Membran. Biospektrum 21, 706–708 (2015). https://doi.org/10.1007/s12268-015-0634-3

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  • DOI: https://doi.org/10.1007/s12268-015-0634-3

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