Abstract
The vast majority of secretory proteins is characterized by N-terminal signal peptides that allow for co-translational translocation into the lumen of the endoplasmic reticulum, the initial compartment of the classical ER/Golgi-dependent secretory pathway. However, extracellular proteins with fundamental physiological functions in immune surveillance and tissue organization have been identified that lack signal peptides. The molecular mechanisms by which these unconventional secretory proteins reach the extracellular space are beginning to emerge.
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Julia P. Steringer Jahrgang 1983. Biologiestudium an der Universität Heidelberg und an der ETH Zürich, Schweiz. 2012 Promotion, danach Postdoc am Biochemie-Zentrum der Universität Heidelberg.
Hans-Michael Müller Jahrgang 1959. Biologiestudium an der Universität Heidelberg. 1989 Promotion. 1990 Postdoc am Zentrum für Molekulare Biologie Heidelberg (ZMBH). 1991–1995 Postdoc am Institut für Parasitologie der Universität La Sapientia, Rom, Italien. 1996–2005 wissenschaftlicher Mitarbeiter am European Molecular Biology Laboratory (EMBL), Heidelberg. 2001 Habilitation an der Universität Heidelberg. 2006 wissenschaftlicher Mitarbeiter am ZMBH. Seit 2007 Senior Scientist in der Arbeitsgruppe Nickel am Biochemie-Zentrum der Universität Heidelberg (BZH).
Walter Nickel Jahrgang 1964. Biologiestudium an der Universität Göttingen. 1994 Promotion. 1994–1997 Postdoc am Institut für Biochemie I, Universität Heidelberg. 1997–2000 Postdoc am Memorial Sloan Kettering Cancer Center New York, USA. 2001 Habilitation im Fach Biochemie an der Universität Heidelberg. Seit 2004 Professor für Biochemie, Biochemie-Zentrum der Universität Heidelberg (BZH).
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Steringer, J.P., Müller, HM. & Nickel, W. Die molekulare Entschlüsselung unkonventioneller Sekretionsmechanismen. Biospektrum 20, 400–403 (2014). https://doi.org/10.1007/s12268-014-0456-8
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DOI: https://doi.org/10.1007/s12268-014-0456-8