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R-Spondine: Einblicke in die Potenzierung der Wnt-Signaltransduktion

  • Wissenschaft · Special: Zellbiologie
  • Strukturbiologie
  • Published:
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Abstract

Intercellular signalling by Wnt morphogenetic proteins is subject to a multi-layered system of regulation. The four secreted R-spondin proteins potentiate Wnt signalling in vertebrates. They are involved in embryogenesis, adult stem cell biology and cancer progression and have been proven essential for ex vivo culturing of organoids. Recent research has generated profound new insights into how R-spondins function to stabilize Wnt receptors of the Frizzled family at the cell surface.

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Authors and Affiliations

  1. Division of Structural Biology (Strubi), Henry Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

    Matthias Zebisch & E. Yvonne Jones

  2. The Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford, OX3 7BN, UK

    Matthias Zebisch

Authors
  1. Matthias Zebisch
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  2. E. Yvonne Jones
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Correspondence to Matthias Zebisch.

Additional information

Matthias Zebisch 1998–2003 Biochemiestudium an der Universität Halle/Saale. 2008 Promotion am Biotechnologisch-Biomedizinischen Zentrum der Universität Leipzig; dort bis 2010 Postdoc. Seit 2011 Postdoc am Wellcome Trust Center for Human Genetics, Oxford, UK. 2011–2013 Marie Curie-IEF-Stipendiat.

E. Yvonne Jones 1985 Promotion in Molekularer Biophysik, Universität Oxford, UK. 1995–1991 Postdoc an den Universitäten Edinburgh und Oxford, UK. Seit 1991 Arbeitsgruppenleiterin an der Universität Oxford. 1999 Professor für Proteinkristallografie. Seit 2008 Leiterin der Abteilung Strukturbiologie (STRUBI) am Wellcome Trust Center for Human Genetics, Oxford.

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Zebisch, M., Yvonne Jones, E. R-Spondine: Einblicke in die Potenzierung der Wnt-Signaltransduktion. Biospektrum 20, 395–399 (2014). https://doi.org/10.1007/s12268-014-0455-9

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  • DOI: https://doi.org/10.1007/s12268-014-0455-9

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