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Antioxidants Supplementation During Exercise: Friends or Enemies for Cardiovascular Homeostasis?

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Abstract

Exercise is a preferred strategy for improving cardiac function, especially for patients with cardiovascular diseases. Increasing evidence indicates that oxidative stress is involved in exercise-induced cardioprotection, while the underlying mechanism remains unclear. Furthermore, the effect of antioxidant supplementation during or post-exercise still exists despite divergences. To explore the effect of oxidative stress and antioxidant supplementation on cardiovascular homeostasis during or post-exercise, we take insights into the progress of exercise-induced oxidative stress, antioxidant supplementation, and cardiovascular homeostasis. In particular, antioxidants such as vitamin C or E, gamma-oryzanol, and other natural antioxidants are discussed concerning regulating exercise-associated oxidative stress. Additionally, our present study reviewed and discussed a meta-analysis of antioxidant supplementation during exercise. Overall, we take an insight into the essential biological adaptations in response to exercise and the effects of antioxidant supplementation on cardiac function, which aid us in giving recommendations on antioxidant supplementation for exercisers and exercised people. A better understanding of these issues will broaden our knowledge of exercise physiology.

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Abbreviations

CVD:

Cardiovascular disease

ROS:

Reactive oxygen species

MI:

Myocardial infarction

EVs:

Extracellular vesicles

IRI:

Ischemia-reperfusion injury

Sirt 3:

Silent mating type information regulation 2 homolog 3

SOD2:

Superoxide dismutase 2

PGC-1α:

Peroxisome proliferator-activated receptor-γ coactlvator-1α

Nrf2:

Nuclear factor erythroid 2-related factor 2

miRNAs:

Micro-RNAs

PDE5:

CGMP‑specific phosphodiesterase type 5

Sir2:

SILENT information regulator 2

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Funding

This work was supported by the grants from the National Key Research and Development Project (2018YFE0113500 to JJ Xiao), the National Natural Science Foundation of China (82020108002, and 81911540486 to JJ Xiao, 82000253 to HY Wang), the grant from Science and Technology Commission of Shanghai Municipality (20DZ2255400 and 21XD1421300 to JJ Xiao), the “Dawn” Program of Shanghai Education Commission (19SG34 to JJ Xiao), the Sailing Program from Science and Technology Commission of Shanghai (20YF1414000 to HY Wang), “Chenguang Program” of Shanghai Education Development Foundation, and Shanghai Municipal Education Commission (20CG46 to HY Wang).

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  1. Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People’s Hospital of Nantong), School of Medicine, Shanghai University, Nantong, 226011, China

    Hongyun Wang & Junjie Xiao

  2. Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, School of Life Science, Shanghai University, 333 Nan Chen Road, Shanghai, 200444, China

    Hongyun Wang, Zijiang Yang, Xiao Zhang, Jinxin Xie, Yuling Xie & Junjie Xiao

  3. Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA

    Priyanka Gokulnath

  4. Institute of Biochemistry and Cellular Biology, National Research Council of Italy, 80131, Naples, Italy

    Gururaja Vulugundam

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  1. Hongyun Wang
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Wang, H., Yang, Z., Zhang, X. et al. Antioxidants Supplementation During Exercise: Friends or Enemies for Cardiovascular Homeostasis?. J. of Cardiovasc. Trans. Res. 16, 51–62 (2023). https://doi.org/10.1007/s12265-022-10297-y

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