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The Role of Angiogenesis and Arteriogenesis in Myocardial Infarction and Coronary Revascularization

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A Correction to this article was published on 11 April 2022

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Abstract

Surgical myocardial revascularization is associated with long-term survival benefit in patients with multivessel coronary artery disease. However, the exact biological mechanisms underlying the clinical benefits of myocardial revascularization have not been elucidated yet. Angiogenesis and arteriogenesis biologically leading to vascular collateralization are considered one of the endogenous mechanisms to preserve myocardial viability during ischemia, and the presence of coronary collateralization has been regarded as one of the predictors of long-term survival in patients with coronary artery disease (CAD). Some experimental studies and indirect clinical evidence on chronic CAD confirmed an angiogenetic response induced by myocardial revascularization and suggested that revascularization procedures could constitute an angiogenetic trigger per se. In this review, the clinical and basic science evidence regarding arteriogenesis and angiogenesis in both CAD and coronary revascularization is analyzed with the aim to better elucidate their significance in the clinical arena and potential therapeutic use.

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Authors and Affiliations

  1. Cardiac Surgery, Massachusetts General Hospital & Harvard Medical School, Boston, USA

    Cristiano Spadaccio & Gus J. Vlahakes

  2. Cardiac Surgery, Golden Jubilee National Hospital & University of Glasgow, Glasgow, UK

    Cristiano Spadaccio

  3. Cardiac Surgery, Università Campus Bio-Medico di Roma, Rome, Italy

    Antonio Nenna & Massimo Chello

  4. Cardiac Surgery, Lancashire Cardiac Centre, Blackpool Victoria Hospital, Blackpool, UK

    David Rose

  5. Cardiology, Università Campus Bio-Medico di Roma, Rome, Italy

    Francesco Piccirillo, Annunziata Nusca & Francesco Grigioni

Authors
  1. Cristiano Spadaccio
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  2. Antonio Nenna
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  3. David Rose
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  4. Francesco Piccirillo
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  5. Annunziata Nusca
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  6. Francesco Grigioni
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  7. Massimo Chello
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  8. Gus J. Vlahakes
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Cristiano Spadaccio, Antonio Nenna, David Rose and Francesco Piccirillo. The first draft of the manuscript was written by Cristiano Spadaccio, Antonio Nenna, David Rose and Francesco Piccirillo. Critical revision of the manuscript was performed by Annunziata Nusca, Francesco Grigioni, Massimo Chello and Gus Vlahakes. All authors read and approved the final manuscript.

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Correspondence to Cristiano Spadaccio.

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Associate Editor Yihua Bei oversaw the review of this article

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The original version of this article was revised: Due to an error during the production process, space was missing between the words “Arteriogenesis” and “in” in the title of this article as originally published.

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Spadaccio, C., Nenna, A., Rose, D. et al. The Role of Angiogenesis and Arteriogenesis in Myocardial Infarction and Coronary Revascularization. J. of Cardiovasc. Trans. Res. 15, 1024–1048 (2022). https://doi.org/10.1007/s12265-022-10241-0

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