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Relationship of Cardiac Autonomic Modulation with Cardiovascular Parameters in Adults, According to Body Mass Index and Physical Activity

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Abstract

This study aimed to analyze the relationship between cardiac autonomic modulation (CAM) and cardiovascular parameters (blood pressure and resting heart rate) in a sample of 256 adults, grouped by body mass index and sufficient moderate-to-vigorous physical activity (≥150 min/week). The sample showed different cardiovascular parameters and CAM according to body mass index, but not according to physical activity. Adults who are overweight and physically active presented higher relationship between CAM and blood pressure than those who are insufficiently active, similarly to normal weight groups. Recommended levels of physical activity may play an important role in the relationship of HRV with cardiovascular parameters in overweight adults, regardless of sex, age, socioeconomic level, and central fat. Trial registration: Registered at ClinicalTrials.gov (NCT03986879).

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Data Availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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List of Abbreviations

HRV Heart rate variability.

SDNN Standard deviation of the mean of all normal RR intervals.

RMSSD Square root of the square mean of the differences between adjacent normal RR intervals in a time interval.

LF Low frequency in normalized units.

HF High frequency in normalized units.

LF/HF Ratio between Low Frequency and High Frequency.

SD1 Standard deviation of instantaneous beat-to-beat variability.

SD2 Long-term standard deviation of continuous R-R intervals.

SBP Systolic blood pressure.

DBP Diastolic blood pressure.

RHR Resting heart rate.

MVPA Moderate-to-vigorous physical activity.

BMI Body mass index.

Funding

This research was funded by the Fundação de Amparo à Pesquisa do Estado de São Paulo – FAPESP (process number 2017–07321-9).

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Authors and Affiliations

  1. Universidade Estadual Paulista – Unesp, Roberto Simonsen street, number 305, 19060-900, Campus de Presidente Prudente, city of Presidente Prudente, State of Sao Paulo, Brazil

    William R. Tebar, Bruna T. C. Saraiva, Tatiana M. Damato, Leandro D. Delfino, Luiz Carlos M. Vanderlei & Diego G. D. Christofaro

  2. Universidade Nove de Julho – Uninove, Sao Paulo, Brazil

    Raphael M. Ritti-Dias

  3. Faculdade de Desporto da Universidade do Porto, Porto, Portugal

    Jorge Mota

  4. Universidade Federal Rural de Pernambuco, Recife, Brazil

    Breno Q. Farah

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  1. William R. Tebar
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  2. Raphael M. Ritti-Dias
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Contributions

Conception or design of the work: WRT, RMRD, JM, LCMV, and DGDC; Data collection: WRT, BTCS, TMMD, and LDD; Data analysis and/or interpretation of data for the work: WRT, DGDC, and BQF; Drafting the work or revising it critically for important intellectual content: WRT, DGDC, BQF, JM, RMRD, LCMV; Approval of the final version to be published: all the authors.

Corresponding author

Correspondence to William R. Tebar.

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The authors declare there is no conflict of interest in regard this manuscript.

Ethics Approval and Consent to Participate

The research has been performed in accordance with the Declaration of Helsinki and the study belongs to a previously registered protocol (NCT03986879), approved by the Ethical Research Committee of Sao Paulo State University (CAAE: 72191717.9.0000.5402). All the participants signed the Informed Consent form, being informed of the research procedures.

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No individual data was reported in this manuscript; therefore consent for publication is not required.

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Associate Editor Marat Fudim oversaw the review of this article

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Tebar, W.R., Ritti-Dias, R.M., Mota, J. et al. Relationship of Cardiac Autonomic Modulation with Cardiovascular Parameters in Adults, According to Body Mass Index and Physical Activity. J. of Cardiovasc. Trans. Res. 14, 975–983 (2021). https://doi.org/10.1007/s12265-021-10101-3

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