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Activity-Dependent Phosphorylation of CDKL5 at Serine 407 Regulates Synaptogenesis and Plasticity

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Acknowledgments

We thank Dr. Bin Lu and Dr. Yong-Chuan Zhu for their critical comments on the manuscript. We thank Dr. Qian Hu, Dan Xiang, and Xuxin Chen from the Optical Imaging Core Facility at the Institution of Neuroscience (ION) for assistance with confocal imaging, Ms. Ling Han of the ION Animal Facility for assistance with animal care, and Molecular and Cellular Biology Core Facility. This work was supported by the Ministry of Science and Technology (2018YFA0801404), and the Shanghai Municipal Science and Technology Major Project (2018SHZDZX05).

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Authors and Affiliations

  1. Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China

    Mengying Jiang, Qiwu Xu, Can Yang, Dan Li, Yuxian Zhang & Zhi-Qi Xiong

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Mengying Jiang & Zhi-Qi Xiong

  3. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China

    Ji-Wei Liu & Yong-Chuan Zhu

  4. Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, 201210, China

    Zhi-Qi Xiong

  5. School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China

    Zhi-Qi Xiong

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  1. Mengying Jiang
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Correspondence to Zhi-Qi Xiong.

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Jiang, M., Xu, Q., Yang, C. et al. Activity-Dependent Phosphorylation of CDKL5 at Serine 407 Regulates Synaptogenesis and Plasticity. Neurosci. Bull. 39, 1454–1458 (2023). https://doi.org/10.1007/s12264-023-01066-1

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  • DOI: https://doi.org/10.1007/s12264-023-01066-1

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