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Cognitive Impairment in Idiopathic Normal Pressure Hydrocephalus

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A Correction to this article was published on 25 July 2022

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Abstract

Idiopathic normal pressure hydrocephalus (iNPH) is a significant cause of the severe cognitive decline in the elderly population. There is no cure for iNPH, but cognitive symptoms can be partially alleviated through cerebrospinal fluid (CSF) diversion. In the early stages of iNPH, cognitive deficits occur primarily in the executive functions and working memory supported by frontostriatal circuits. As the disease progresses, cognition declines continuously and globally, leading to poor quality of life and daily functioning. In this review, we present recent advances in understanding the neurobiological mechanisms of cognitive impairment in iNPH, focusing on (1) abnormal CSF dynamics, (2) dysfunction of frontostriatal and entorhinal-hippocampal circuits and the default mode network, (3) abnormal neuromodulation, and (4) the presence of amyloid-β and tau pathologies.

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Acknowledgments

This review was supported by the National Natural Science Foundation of China (31961133025).

Author information

Authors and Affiliations

  1. Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China

    Haoyun Xiao & Zheng Ye

  2. University of Chinese Academy of Sciences, Beijing, 100049, China

    Haoyun Xiao

  3. Department of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

    Fan Hu

  4. Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China

    Jing Ding

Authors
  1. Haoyun Xiao
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  2. Fan Hu
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  3. Jing Ding
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  4. Zheng Ye
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Corresponding author

Correspondence to Zheng Ye.

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Xiao, H., Hu, F., Ding, J. et al. Cognitive Impairment in Idiopathic Normal Pressure Hydrocephalus. Neurosci. Bull. 38, 1085–1096 (2022). https://doi.org/10.1007/s12264-022-00873-2

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  • DOI: https://doi.org/10.1007/s12264-022-00873-2

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