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Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism

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Abstract

Rapid eye movement sleep behavior disorder (RBD) is one of the most common non-motor symptoms of parkinsonism, and it may serve as a prodromal marker of neurodegenerative disease. The mechanism underlying RBD is unclear. Several prospective studies have reported that specific non-motor symptoms predict a conversion risk of developing a neurodegenerative disease, including olfactory dysfunction, abnormal color vision, autonomic dysfunction, excessive daytime sleepiness, depression, and cognitive impairment. Parkinson’s disease (PD) with RBD exhibits clinical heterogeneity with respect to motor and non-motor symptoms compared with PD without RBD. In this review, we describe the main clinical and pathogenic features of RBD, focusing on its association with other non-motor symptoms of parkinsonism.

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Acknowledgements

This review was supported by the National Natural Science Foundation of China (91649114), the Jiangsu Provincial Special Program of Medical Science, China (BL2014042), a Jiangsu Provincial Medical Key Discipline Project, the Suzhou Clinical Research Center of Neurological Disease (Szzx201503), Jiangsu Province Ordinary University Professional Degree Graduate Practice Innovation, China (SJZZ16-0242), and the Priority Academic Program Development of Jiangsu Higher Education Institutions, China.

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  1. Hong Jin and Jin-Ru Zhang contributed equally to this review.

Authors and Affiliations

  1. Department of Neurology and Sleep Center, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China

    Hong Jin, Jin-Ru Zhang, Yun Shen & Chun-Feng Liu

  2. Institute of Neuroscience, Soochow University, Suzhou, 215123, China

    Chun-Feng Liu

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Jin, H., Zhang, JR., Shen, Y. et al. Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism. Neurosci. Bull. 33, 576–584 (2017). https://doi.org/10.1007/s12264-017-0164-8

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