Skip to main content

Advertisement

SpringerLink
Log in

Concomitant Chest Wall Resection and Reconstruction in a Cohort of 254 Patients of Non-small Cell Lung Cancer Resections Between 2007 and 2019: a 12-Year Experience from a Single Center in Turkey

  • Original Article
  • Published:
Indian Journal of Surgery Aims and scope Submit manuscript

Abstract

Lung cancer with chest wall invasion, which constitute 5–10% of operable non-small cell lung cancer cases, is heterogeneous in terms of factors that may affect the prognosis. We aim to share our experience including the surgical results of patients with non-small cell lung cancer (NSCLC) who underwent chest wall resection and identify the potential factors that may impact survival. The patients who underwent combined chest wall and lung resection due to primary lung cancer invading the chest wall in our center between 2007 and 2019 were reviewed. Variables such as age, tumor size, histological subtype, surgical technique, depth of invasion, the extent of resection, neoadjuvant, and adjuvant treatment status were examined. Two hundred fifty-four patients who underwent combined chest wall and lung resection were included in the study. There were 245 men and 9 women. The mean age was 61.0 SD8.4 years. The overall survival was 70.9 SD4.6 months, and the 5-year survival rate was 41.5 SD3.3%. In multivariate analyses, age, the extent of lung resection, the number of resected ribs, invasion depth, and completeness of chest wall resection were independent factors that have an effect on survival. This study shows that age, the extent of lung and chest wall resection, invasion depth, and completeness of chest wall resection are independent prognostic factors of survival in patients who underwent combined lung and chest wall resection for NSCLC. Institutional Review Board of the Dr Suat Seren Chest Diseases and Surgery Medical Practice and Research Center (No: E-49109414–604.02.02).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Data Availability

The data underlying this article cannot be shared publicly due to the privacy of individuals that participated in the study. The data will be shared on reasonable request to the corresponding author.

Abbreviations

CT:

Computed tomography

DFS:

Disease-free survival

DLCO:

Diffusing capacity of the lungs for carbon monoxide

MRI:

Magnetic resonance imaging

NCCN:

National Comprehensive Cancer Network

NSCLC:

Non-small cell lung cancer

OS:

Overall survival

PET:

Positron emission tomography

VO2max:

Maximal oxygen consumption

References

  1. Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE et al (2016) The IASLC Lung Cancer Staging Project: proposals for revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer. J Thorac Oncol 11(1):39–51

    Article  PubMed  Google Scholar 

  2. Doddoli C, D’Journo B, Le Pimpec-Barthes F, Dujon A, Foucault C, Thomas P et al (2005) Lung cancer invading the chest wall: a plea for en-bloc resection but the need for new treatment strategies. Ann Thorac Surg 80:2032–2040

    Article  PubMed  Google Scholar 

  3. Chapelier A, Fadel E, Macchiarini P, Lenot B, Le Roy LF, Cerrina J et al (2000) Factors affecting long-term survival after en-bloc resection of lung cancer invading the chest wall. Eur J Cardiothorac Surg 18(5):513–518

    Article  CAS  PubMed  Google Scholar 

  4. Facciolo F, Cardillo G, Lopergolo M, Pallone G, Sera F, Martelli M (2001) Chest wall invasion in non-small cell lung carcinoma: a rationale for en bloc resection. J Thorac Cardiovasc Surg 121(4):649–656

    Article  CAS  PubMed  Google Scholar 

  5. Elia S, Griffo S, Gentile M, Costabile R, Ferrante G (2001) Surgical treatment of lung cancer invading chest wall: a retrospective analysis of 110 patients. Eur J Cardiothorac Surg 20(2):356–360

    Article  CAS  PubMed  Google Scholar 

  6. Martin-Ucar AE, Nicum R, Oey I, Edwards JG, Waller DA (2003) En-bloc chest wall and lung resection for non-small cell lung cancer. Predictors of 60-day non-cancer related mortality. Eur J Cardiothorac Surg 23(6):859–64

    Article  CAS  PubMed  Google Scholar 

  7. Filosso PL, Sandri A, Guerrera F, Solidoro P, Bora G, Lyberis P et al (2016) Primary lung tumors invading the chest wall. J Thorac Dis 8(Suppl 11):S855–S862

    Article  PubMed  PubMed Central  Google Scholar 

  8. Coleman FP (1947) Primary carcinoma of the lung with invasion of the ribs: pneumonectomy and simultaneous block resection of the chest wall. Ann Surg 126:156–168

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Pitz CC, Brutel de la Rivière A, Elbers HR, Westermann CJ, van den Bosch JM (1996) Surgical treatment of 125 patients with non-small cell lung cancer and chest wall involvement. Thorax 51:846–850

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Magdeleinat P, Alifano M, Benbrahem C, Spaggiari L, Porrello C, Puyo P et al (2001) Surgical treatment of lung cancer invading the chest wall: results and prognostic factors. Ann Thorac Surg 71(4):1094–9

    Article  CAS  PubMed  Google Scholar 

  11. Riquet M, Lang-Lazdunski L, Le PB, Dujon A, Souilamas R, Danel C et al (2002) Characteristics and prognosis of resected T3 non-small cell lung cancer. Ann Thorac Surg 73(1):253–258

    Article  PubMed  Google Scholar 

  12. Matsuoka H, Nishio W, Okada M, Sakamoto T, Yoshimura M, Tsubota N (2004) Resection of chest wall invasion in patients with non-small cell lung cancer. Eur J Cardiothorac Surg 26(6):1200–1204

    Article  PubMed  Google Scholar 

  13. Lin YT, Hsu PK, Hsu HS, Huang CS, Wang LS, Huang BS et al (2006) En bloc resection for lung cancer with chest wall invasion. J Chin Med Assoc 69(4):157–161

    Article  PubMed  Google Scholar 

  14. Lee CY, Byun CS, Lee JG, Kim DJ, Cho BC, Chung KY et al (2012) The prognostic factors of resected non-small cell lung cancer with chest wall invasion. World J Surg Oncol 12(10):9

    Article  Google Scholar 

  15. Kumar N, Malik PS, Bharati SJ, Yadav M, Jain D, Kumar S (2021) Primary lung cancer with chest wall involvement: outcomes of a multimodality management approach. Lung India 38(4):338–342

    Article  PubMed  PubMed Central  Google Scholar 

  16. Stoelben E, Ludwig C (2009) Chest wall resection for lung cancer: indications and techniques. Eur J Cardiothorac Surg 35:450–456

    Article  PubMed  Google Scholar 

  17. - National Comprehensive Cancer Network (2023) Non-Small Cell Lung Cancer (Version 2.2023). https://www.nccn.org/professionals/physician_gls/pdf/nscl.pdf. Accessed 18 Feb 2013

  18. Riquet M, Pricopi C, Mangiameli G, Arame A, Badia A, Le Pimpec BF (2017) Occult pN2 disease in lung cancer patients: a wide range of diseases endangering the long term prognosis. J Thorac Dis 9(8):2271–2275

    Article  PubMed  PubMed Central  Google Scholar 

  19. Kim MP, Correa AM, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Erasmus JJ, Swisher SG (2018) Occult stage IIIA-N2 patients have excellent overall survival with initial surgery. J Thorac Dis 10(12):6670–6676

    Article  PubMed  PubMed Central  Google Scholar 

  20. Downey RJ, Martini N, Rusch VW, Bains MS, Korst RJ, Ginsberg RJ (1999) Extent of chest wall invasion and survival in patients with lung cancer. Ann Thorac Surg 68:188–193

    Article  CAS  PubMed  Google Scholar 

  21. Caldarella A, Crocetti E, Comin CE, Janni A, Lopes Pegna A, Paci E (2007) Gender differences in non-small cell lung cancer: a population study. Eur J Surg Oncol 33:763–768

    Article  CAS  PubMed  Google Scholar 

  22. Pfannschmidt J, Muley T, Bulzebruck H, Hoffman H, Dienemann H (2007) Prognostic assessment after surgical resection for non-small cell lung cancer: experiences in 2,083 patients. Lung Cancer 55:371–377

    Article  PubMed  Google Scholar 

  23. Wang BY, Huang JY, Chen HC, Lin CH, Lin SH, Hung WH et al (2020) The comparison between adenocarcinoma and squamous cell carcinoma in lung cancer patients. J Cancer Res Clin Oncol 146(1):43–52

    Article  PubMed  Google Scholar 

  24. Pignon JP, Tribodet H, Scagliotti GV, Douillard JY, Shepherd FA, Stephens RJ et al (2008) Lung adjuvant cisplatin evaluation: a pooled analysis by theLACE Collaborative Group. J Clin Oncol 26:3552–3559

    Article  PubMed  Google Scholar 

  25. Arriagada R, Auperin A, Burdett S, Higgins JP, Johnson DH, Le Chevalier T et al (2010) Adjuvant chemotherapy, with or without postoperative radiotherapy, inoperable non-small-cell lung cancer: two meta-analyses of individual patientdata. Lancet 375:1267–1277

    Article  CAS  PubMed  Google Scholar 

  26. Chiappetta M, Nachira D, Congedo MT, Meacci E, Porziella V, Margaritora S (2019) Non-small cell lung cancer with chest wall involvement: integrated treatment or surgery alone? Thorac Cardiovasc Surg 67(4):299–305. https://doi.org/10.1055/s-0038-1632363

    Article  PubMed  Google Scholar 

  27. Kawaguchi K, Yokoi K, Niwa H, Ohde Y, Mori S, Okumura S et al (2017) Central Japan Lung Study Group. A prospective, multi-institutional phase II study of induction chemoradiotherapy followed by surgery in patients with non-small cell lung cancer involving the chest wall (CJLSG0801). Lung Cancer 104:79–84

    Article  PubMed  Google Scholar 

  28. Fedor D, Johnson WR, Singhal S (2013) Local recurrence following lung cancer surgery: incidence, risk factors, and outcomes. Surg Oncol 22(3):156–161

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Thoracic Surgery, Kars Harakani State Hospital, Yenişehir, Ismail Aytemiz 55, 36002, Kars, Turkey

    Güntuğ Batıhan

  2. Dr. Suat Seren Chest Diseases and Chest Surgery Training and Research Center, Department of Thoracic Surgery, University of Health Sciences Turkey, Izmir, Turkey

    Ahmet Üçvet, Serkan Yazgan, Kenan Can Ceylan & Seyda Örs Kaya

  3. Faculty of Medicine, Department of Thoracic Surgery, Izmir Bakircay University, Izmir, Turkey

    Soner Gürsoy

Authors
  1. Güntuğ Batıhan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ahmet Üçvet
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Serkan Yazgan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kenan Can Ceylan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Soner Gürsoy
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Seyda Örs Kaya
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

GB: Conceptualization; Data curation; Formal analysis; Investigation; Methodology; Supervision; Writing—review & editing.

AU: Conceptualization; Data curation; Formal analysis; Investigation; Methodology; supervision; Writing—original draft; Writing—review & editing.

SY: Conceptualization; Methodology; Project administration; Writing—original draft; Writing—review & editing.

KCC: Conceptualization; Data curation; Investigation; Methodology; Project administration; Writing—original draft; Writing—review & editing.

SG: Investigation; Methodology; Writing—review & editing.

SOK: Conceptualization; Investigation; Methodology; Project administration; Writing—original draft; Writing—review & editing.

Corresponding author

Correspondence to Güntuğ Batıhan.

Ethics declarations

Ethics Approval and Consent to Participate

This study was approved by the Institutional Review Board (E-49109414–604.02.02). All methods were performed in accordance with the relevant guidelines and regulations (Declaration of Helsinki). Informed consent was obtained from patients for study participation.

Consent for Publication

Not applicable.

Competing Interests

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Batıhan, G., Üçvet, A., Yazgan, S. et al. Concomitant Chest Wall Resection and Reconstruction in a Cohort of 254 Patients of Non-small Cell Lung Cancer Resections Between 2007 and 2019: a 12-Year Experience from a Single Center in Turkey. Indian J Surg 85 (Suppl 2), 424–433 (2023). https://doi.org/10.1007/s12262-023-03768-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12262-023-03768-2

Keywords

Search

Navigation