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Use of 2% Hydrogen Peroxide on Split-Thickness Skin Grafts in Diabetic Patients: a Case Series Analysis with Excellent Results

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Abstract

Hydrogen peroxide (H2O2) is a commonly used antiseptic in surgical practice. However, little is known of its dose-dependent toxicity and benefits. In this study, we bring out the outcome of application of 2% H2O2 soaks on split skin thickness graft (STSG) post-operatively and discuss the rationale behind using them in daily clinical practice. This is a case series analysis of four patients with similar profile who were admitted and subsequently managed over a period of six to 8 weeks at a zonal hospital. All four patients went through similar pre- and post-STSG regime which includes application of 2% H2O2 soaks on post-operative day (POD) 05. There was negligible graft loss in all operated patients after application of 2% H2O2 soaks on POD 05. This study brings out the differences in outcome in diabetic patients with a different and novel treatment protocol which envisages post-operative application of H2O2 soaks on STSG. It also brings out the concentration-dependent properties of H2O2 which can be applied to clinical practice and further improve the management of chronic non-healing diabetic wounds.

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Authors and Affiliations

  1. Military Hospital, Uttar Pradesh, Meerut, India

    Ankit Sharma, Gaurav Panchal & Isha Sharma

  2. Military Hospital, Bhatinda, Punjab, India

    Deep Shikha

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  1. Ankit Sharma
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  2. Deep Shikha
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  3. Gaurav Panchal
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  4. Isha Sharma
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Contributions

All authors performed all the tasks in this study.

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Correspondence to Gaurav Panchal.

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The authors declare no competing interests.

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Sharma, A., Shikha, D., Panchal, G. et al. Use of 2% Hydrogen Peroxide on Split-Thickness Skin Grafts in Diabetic Patients: a Case Series Analysis with Excellent Results. Indian J Surg 85, 322–328 (2023). https://doi.org/10.1007/s12262-022-03432-1

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  • DOI: https://doi.org/10.1007/s12262-022-03432-1

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