Abstract
We described a case of low-grade fibromatosis-like spindle cell carcinoma (FLSCC) of the breast of a 49-year-old woman, which was diagnosed by excisional biopsy. The histopathology was characterized by bland neoplastic spindle cells with mild or no nuclear atypia, mimicking a benign mesenchymal tumor. An immunopanel of markers including pancytokeratin, p63, smooth muscle actin (SMA), CD10, and β-catenin was performed to establish the diagnosis and exclude other mimickers. The patient subsequently received modified radical mastectomy and was alive without disease for 10-year follow-up. Low-grade fibromatosis-like spindle cell carcinoma is a rare subtype of metaplastic carcinomas of the breast and typically occurs as palpable breast mass in an older woman. It can be histologically confused with nodular fasciits, desmoids-type fibromatosis, and inflammatory myofibroblastic tumor. Immunohistochemical study was essential for a correct diagnosis. It behaves as a locally aggressive disease but with a low potential of regional lymph node or distant metastasis.
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References
Gobbi H, Simpson JF, Borowsky A, Jensen RA, Page DL (1999) Metaplastic breast tumors with a dominant fibromatosis-like phenotype have a high risk of local recurrence. Cancer 85(10):2170–2182. https://doi.org/10.1002/(sici)1097-0142(19990515)85:10<2170::aid-cncr11>3.0.co;2-x
Ellis IO, Bell J, Ronan JE, Elston CW, Blamey RW (1988) Immunocytochemical investigation of intermediate filament proteins and epithelial membrane antigen in spindle cell tumours of the breast. J Pathol 154(2):157–165. https://doi.org/10.1002/path.1711540208
Kaufman MW, Marti JR, Gallager HS, Hoehn JL (1984) Carcinoma of the breast with pseudosarcomatous metaplasia. Cancer 53(9):1908–1917. https://doi.org/10.1002/1097-0142(19840501)53:9<1908::aid-cncr2820530917>3.0.co;2-f
Nonnis R, Paliogiannis P, Giangrande D, Marras V, Trignano M (2012) Low-grade fibromatosis-like spindle cell metaplastic carcinoma of the breast: a case report and literature review. Clin Breast Cancer 12(2):147–150. https://doi.org/10.1016/j.clbc.2012.01.011
Dwyer JB, Clark BZ (2015) Low-grade fibromatosis-like spindle cell carcinoma of the breast. Arch Pathol Lab Med 139(4):552–557. https://doi.org/10.5858/arpa.2013-0555-RS
Takano EA, Hunter SM, Campbell IG, Fox SB (2015) Low-grade fibromatosis-like spindle cell carcinomas of the breast are molecularly exiguous. J Clin Pathol 68(5):362–367. https://doi.org/10.1136/jclinpath-2014-202824
Sneige N, Yaziji H, Mandavilli SR, Perez ER, Ordonez NG, Gown AM, Ayala A (2001) Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. Am J Surg Pathol 25(8):1009–1016. https://doi.org/10.1097/00000478-200108000-00004
Khan HN, Wyld L, Dunne B, Lee AH, Pinder SE, Evans AJ, Robertson JF (2003) Spindle cell carcinoma of the breast: a case series of a rare histological subtype. Eur J Surg Oncol 29(7):600–603. https://doi.org/10.1016/s0748-7983(03)00107-0
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Chen, HY., Nguyen, T.M.T. & Chang, IW. Low-Grade Fibromatosis-Like Spindle Cell Carcinoma of the Breast: a Mimicker of Benign Mesenchymal Tumors. Indian J Surg 83 (Suppl 2), 535–538 (2021). https://doi.org/10.1007/s12262-020-02142-w
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DOI: https://doi.org/10.1007/s12262-020-02142-w