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Challenges in the Surgical Treatment of Retroperitoneal Sarcomas

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Abstract

The objective of this study is to assess long-term prognosis and patterns of failure in patients with retroperitoneal sarcoma who underwent surgery with curative intent at a single institution. We also provide a thorough review of the literature including several series and widely variable data regarding local and distant failure. During a 25-year period (1988–2013), 45 consecutive patients who underwent surgery for retroperitoneal sarcoma at a single referral center were reviewed retrospectively. We recorded and analyzed the presenting symptoms, type of surgical excision, and the 5-year survival rate as well as the local recurrence rate of patients with complete tumor resection. Overall survival is significantly diminished in patients in whom resection margins are not adequate. In our series, 5-year recurrence rate for patients with complete and incomplete resection of the tumor was 30.76 and 68.42 %, respectively. The 5-year survival rate was 51.12 %, and the 5-year survival rate according to type of resection was 76.93 % for complete and 15.79 % for incomplete resections. Local recurrence after first surgery and high-grade malignancy are associated with poor survival. The role of radiation therapy and chemotherapy in the treatment of retroperitoneal sarcoma (RPS) should be investigated further. Complete en bloc resection of the tumor mass and adjacent structures is the single most important factor that improves survival.

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Funding

We received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Conflicts of interest

None declared. The authors have no conflict of interest.

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Authors and Affiliations

  1. 2nd Department of Propedeutic Surgery, University of Athens, Medical School, “Laikon” General Hospital, Agiou Thoma 17, Goudi, 11527, Athens, Greece

    Petros Konofaos, Eleftherios Spartalis, Demetrios Moris, Antonios Athanasiou, Dimitrios Dimitroulis, Charalampos Markakis, Ioannis D. Kostakis, Nikolaos Nikiteas & Gregory Kouraklis

  2. Anastasiou Gennadiou 56, 11474, Athens, Greece

    Demetrios Moris

Authors
  1. Petros Konofaos
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  2. Eleftherios Spartalis
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  3. Demetrios Moris
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  4. Antonios Athanasiou
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  5. Dimitrios Dimitroulis
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  6. Charalampos Markakis
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  7. Ioannis D. Kostakis
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  8. Nikolaos Nikiteas
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  9. Gregory Kouraklis
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Correspondence to Demetrios Moris.

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Konofaos, P., Spartalis, E., Moris, D. et al. Challenges in the Surgical Treatment of Retroperitoneal Sarcomas. Indian J Surg 78, 1–5 (2016). https://doi.org/10.1007/s12262-015-1292-x

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  • DOI: https://doi.org/10.1007/s12262-015-1292-x

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