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Characterization and Anti-inflammatory Effects of Gamma-irradiation on Undaria pinnatifida Root Water Extracts

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Abstract

In this study, characterization and anti-inflammatory activity of Undaria pinnatifida root (UPR) water extracts treated by gamma (γ)-irradiation were investigated. The UPR powder was dissolved in distilled water to form UPR water extracts. Subsequently, they were irradiated with cobalt-60 γ-rays in a dose range from 3 to 20 kGy. In the reducing sugar and viscosity analyses, the reducing sugar content showed a two-fold increase at 20 kGy compared to the non-irradiated control, and UPR water extracts viscosity decreased with increasing irradiation dose. Using thin layer chromatography (TLC), UPR polysaccharides were degraded to monosaccharides after γ-irradiation treatment. Moreover, UPR water extracts treated with γ-irradiation inhibited the production of nitric oxide (NO) and pro-inflammatory cytokine (IL-6 and TNF-α) activity. Therefore, γ-irradiation not only degrades UPR water extracts polysaccharides, but also increases the anti-inflammatory activity of UPR water extracts.

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Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2012R1A6A1028677) and the Nuclear R&D Program of Ministry of Science and ICT.

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Authors and Affiliations

  1. Department of Food Science and Technology, Pukyong National University, Busan, 48513, Korea

    Xiaotong Xu, Ji-Eun Lee, Woo-Sin Kang, Si-Hyeong Ryu & Dong-Hyun Ahn

  2. Institute of Fisheries Sciences, Pukyong National University, Busan, 46041, Korea

    So-Mi Jeong

  3. Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, 56212, Korea

    Eui-Baek Byun

  4. Department of Food Science & Technology, Kongju National University, Yesan, 32439, Korea

    Kwangwook Kim & Eui-Hong Byun

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  1. Xiaotong Xu
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Correspondence to Dong-Hyun Ahn.

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Xu, X., Jeong, SM., Lee, JE. et al. Characterization and Anti-inflammatory Effects of Gamma-irradiation on Undaria pinnatifida Root Water Extracts. Biotechnol Bioproc E 26, 606–611 (2021). https://doi.org/10.1007/s12257-020-0325-x

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  • DOI: https://doi.org/10.1007/s12257-020-0325-x

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