Skip to main content

Advertisement

SpringerLink
Log in

Combined Treatment with Autologous CIK Cells, Radiotherapy and Chemotherapy in Advanced Cervical Cancer

  • Original Article
  • Published:
Pathology & Oncology Research

Abstract

To investigate the clinical efficacy of autologous cytokine induced killer (CIK) cells transfusion combined with radiochemotherapy in the treatment of advanced cervical cancer. A total of 89 hospitalized patients with advanced cervical cancer were admitted and divided into the treatment group (44 cases, autologous CIK cells transfusion combined with radiochemotherapy) and the control group (45 cases, radiochemotherapy) by a randomized non-blind method. Comparisons of therapeutic efficacies, immune functions, life qualities and survival rates were analyzed between the two groups. The short-term therapeutic efficacy of the treatment group was significantly higher than that of the control group. There was no significant difference in 1, 2 and 3 year survival rates between the two groups. Compared with pre-treatment, levels of CD3+, CD4+/CD8+ in peripheral blood were increased in the CIK group, which were reduced in the control group. In the CIK group,only the feeling was depressed on the 25th day post-treatment (T25) compared with the day before treatment (B1). However in the control group, the function of body, role, social and holistic health was obvious disordered on day T25 compared with day B1. On day T25, there were significant differences in function of body, social and holistic health between two groups. Autologous CIK cells transfusion combined with radiochemotherapy shows better short-term efficacy than radiochemotherapy alone in the treatment of advanced cervical cancer, which obviously improves immune function and life quality of patients with low side effects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hu Y, Sun X, Mao C, et al (2017) Upregulation of long noncoding RNA TUG1 promotes cervical cancer cell proliferation and migration. Cancer Med 6(2):471–482

  2. Artan, I.M., et al., The knowledge, attitude and behavioral-intent regarding cervical cancer and the human papillomavirus (HPV) vaccine: A cross-sectional study among female university students in Ajman, UAE

  3. Ferlay J et al (2010) Cancer incidence and mortality worldwide: IARC CancerBase no.11. IARC 136(5):E359–E386

  4. Vidal JP et al (2015) Genetic diversity of HPV16 and HPV18 in Brazilian patients with invasive cervical cancer. J Med Virol 88(7):1279–1287

    Article  CAS  Google Scholar 

  5. Haque W, Verma V, Fakhreddine M, Hatch S, Butler EB, Teh BS (2017) Addition of chemotherapy to definitive radiotherapy for IB1 and IIA1 cervical cancer: analysis of the National Cancer Data Base. Gynecol Oncol 144(1):28–33

    Article  PubMed  Google Scholar 

  6. Zheng Y, Hu B, Xie S, Chen X, Hu Y, Chen W, Li S, Hu B (2017) Dendritic cells infected by ad-sh-SOCS1 enhance cytokine-induced killer (CIK) cell immunotherapeutic efficacy in cervical cancer models. Cytotherapy 19(5):617–628

    Article  CAS  PubMed  Google Scholar 

  7. Niam M, Linn YC, Fook Chong S, Lim TJ, Chu S, Choong A, Yong HX, Suck G, Chan M, Koh M (2011) Clinical scale expansion of cytokine-induced killer cells is feasible from healthy donors and patients with acute and chronic myeloid leukemia at various stages of therapy. Exp Hematol 39(9):897–903.e1

    Article  CAS  PubMed  Google Scholar 

  8. Arber C, Abhyankar H, Heslop HE, Brenner MK, Liu H, Dotti G, Savoldo B (2013) The immunogenicity of virus-derived 2A sequences in immunocompetent individuals. Gene Ther 20(9):958–962

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Liu AM et al (2011) Antitumor effects of cytokine- induced killer cells on cervical cancer HeLa cells in vitro and in vivo. Carcino, Terato & Muta 23(5):353–161

  10. Kim HM, Lim J, Kang JS, Park SK, Lee K, Kim JY, Kim YJ, Hong JT, Kim Y, Han SB (2009) Inhibition of human cervical carcinoma growth by cytokine-induced killer cells in nude mouse xenograft model. Int Immunopharmacol 9(3):375–380

    Article  CAS  PubMed  Google Scholar 

  11. Green JA, Kirwan JM, Tierney JF, Symonds P, Fresco L, Collingwood M, Williams CJ (2001) Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis. Lancet 358(9284):781–786

    Article  CAS  PubMed  Google Scholar 

  12. Zagon IS, Mclaughlin PJ (2012) Targeting opioidergic pathways as a novel biological treatment for advanced pancreatic cancer. Expert Rev Gastroent 6(2):133–135

    Article  Google Scholar 

  13. Mesiano G, Todorovic M, Gammaitoni L, Leuci V, Giraudo Diego L, Carnevale-Schianca F, Fagioli F, Piacibello W, Aglietta M, Sangiolo D (2012) Cytokine-induced killer (CIK) cells as feasible and effective adoptive immunotherapy for the treatment of solid tumors. Expert Opin Biol Ther 12(6):673–684

    Article  CAS  Google Scholar 

  14. Jonathan Benjamin M (2013) Early infusion of donor-derived CIK cells as consolidative immunotherapy following non-Myeloablative allogeneic transplantation: safety and feasibility. Blood 122

  15. Linn YC, Yong HX, Niam M, Lim TJ, Chu S, Choong A, Chuah C, Goh YT, Hwang W, Loh Y, Ng HJ, Suck G, Chan M, Koh M (2012) A phase I/II clinical trial of autologous cytokine-induced killer cells as adjuvant immunotherapy for acute and chronic myeloid leukemia in clinical remission. Cytotherapy 14(7):851–859

    Article  CAS  PubMed  Google Scholar 

  16. Geng J, Zhang Q, Tong J (2016) Effect of chemoradiation combined with DC-CIK cells biological therapy on the treatment of patients with middle-advanced non-small cell lung cancer. J Clin Med in Prac 20(9):48–50

  17. Shi L et al (2012) Adjuvant immunotherapy with CIK cells for stage III gastric Cancer. J Basic Clin Onco 25(3):62–65

    Google Scholar 

  18. Luo X et al (2016) Curative effect of autologous DC-CIK cells on metastatic renal cell carcinoma. J Mod Oncol 15:2426–2429

  19. Chen B et al (2015) Effectiveness of immune therapy combined with chemotherapy on the immune function and recurrence rate of cervical cancer. Exp Ther Med 9(3):1063–1067

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

This study was supported by the Science and Technology Research Projects of Kaifeng City.

Author information

Authors and Affiliations

  1. The Center of Tumor Diagnosis and Treatment, Kaifeng Central Hospital, No.85 Hedao Street, Longting District, Kaifeng, 475001, Henan, China

    Ning Li, Yong-Wei Tian, Yue Xu, Dan-Dan Meng, Ling Gao & Zhi-Qiao Xu

  2. The Department of Statistics, Kaifeng Central Hospital, No.85 Hedao Street, Longting District, Kaifeng, 475001, Henan, China

    Wen-jie Shen & Zong-lan Liu

Authors
  1. Ning Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yong-Wei Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yue Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dan-Dan Meng
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ling Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Wen-jie Shen
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zong-lan Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Zhi-Qiao Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zhi-Qiao Xu.

Ethics declarations

Conflict of Interest

The authors report no potential conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, N., Tian, YW., Xu, Y. et al. Combined Treatment with Autologous CIK Cells, Radiotherapy and Chemotherapy in Advanced Cervical Cancer. Pathol. Oncol. Res. 25, 691–696 (2019). https://doi.org/10.1007/s12253-018-0541-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12253-018-0541-2

Keywords

Search

Navigation