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Association and Prognostic Significance of the Functional −1562C/T Polymorphism in the Promoter Region of MMP-9 in Turkish Patients with Gastric Cancer

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Pathology & Oncology Research

Abstract

Matrix metalloproteinases (MMPs) are a group of zinc-dependent peptidases that participate in matrix turnover in solid malignancies. The aim of this study was twofold. First, we sought to investigate under a case–control design the association between the functional −1562C/T polymorphism in the promoter region of MMP-9 and gastric cancer (GC) in a Turkish sample. Second, we examined its prognostic significance in GC patients. A total of 144 subjects were enrolled in the case–control study (79 GC cases and 65 controls). Overall survival (OS) and progression-free survival (PFS) served as the main outcome measures in the longitudinal study. The MMP-9 −1562C/T polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism method. The odds ratio (OR) of GC for the CC genotype relative to the CT+TT genotypes was not significant (OR = 0.89, 95 % confidence interval [CI] = 0.44–1.82, P = 0.75). These results did not change after allowance for age and sex in multivariable regression analysis (OR = 0.81, 95 % CI = 0.40–1.94, P = 0.84). When the MMP-9 −1562C/T polymorphism was analyzed among GC patients in relation to OS and PFS, we found no significant differences between subjects with the CC and CT+TT genotypes. In conclusion, the results of our study did not point toward a major role of the MMP-9 −1562C/T polymorphism in the pathogenesis and clinical course of GC in Turkish subjects.

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Competing Interests

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Medical Oncology, Ali Osman Sonmez Oncology Hospital, Bursa, Turkey

    Nilufer Avcı & Erdem Cubukcu

  2. Department of Medical Genetics, Uludag University Medicine Faculty, Bursa, Turkey

    Mehmet Ture, Serdar Sahinturk, Ali Topak & Tahsin Yakut

  3. Department of Medical Oncology, Uludag University Medicine Faculty, Bursa, Turkey

    Adem Deligonul, Ender Kurt & Turkkan Evrensel

  4. Department of Medical Oncology, Medipol University School of Medicine, İstanbul, Turkey

    Omer Fatih Olmez

  5. Department of Internal Medicine, Uludag University Medicine Faculty, Bursa, Turkey

    Ahmet Bilgehan Şahin

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  1. Nilufer Avcı
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  2. Mehmet Ture
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  3. Adem Deligonul
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  4. Erdem Cubukcu
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  11. Tahsin Yakut
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Correspondence to Nilufer Avcı or Mehmet Ture.

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Avcı, N., Ture, M., Deligonul, A. et al. Association and Prognostic Significance of the Functional −1562C/T Polymorphism in the Promoter Region of MMP-9 in Turkish Patients with Gastric Cancer. Pathol. Oncol. Res. 21, 1243–1247 (2015). https://doi.org/10.1007/s12253-015-9950-7

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  • DOI: https://doi.org/10.1007/s12253-015-9950-7

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