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Survival and proliferation of the lysogenic bacteriophage CTXΦ in Vibrio cholerae

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Virologica Sinica

Abstract

The lysogenic phage CTXΦ of Vibrio cholerae can transfer the cholera toxin gene both horizontally (inter-strain) and vertically (cell proliferation). Due to its diversity in form and species, the complexity of regulatory mechanisms, and the important role of the infection mechanism in the production of new virulent strains of V. cholerae, the study of the lysogenic phage CTXΦ has attracted much attention. Based on the progress of current research, the genomic features and their arrangement, the host-dependent regulatory mechanisms of CTXΦ phage survival, proliferation and propagation were reviewed to further understand the phage’s role in the evolutionary and epidemiological mechanisms of V. cholerae.

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Authors and Affiliations

  1. State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China

    Fenxia Fan & Biao Kan

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  1. Fenxia Fan
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  2. Biao Kan
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Correspondence to Fenxia Fan.

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ORCID: 0000-0003-1873-4291

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Fan, F., Kan, B. Survival and proliferation of the lysogenic bacteriophage CTXΦ in Vibrio cholerae . Virol. Sin. 30, 19–25 (2015). https://doi.org/10.1007/s12250-014-3550-7

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