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Improved Anti-inflammatory Activity and Minimum Systemic Absorption from Topical Gels of Ibuprofen Formulated by Micelle or Nanoemulsion

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Abstract

Purpose

Few studies have so far described the improved activity of NSAIDs when formulated into nanoemulsions to be applied topically. However, no report is yet available about the topical application of micelles containing NSAIDs. Additionally, the serum concentration of drugs following topical application of nanoemulsions/micelles has not been reported to this point.

Methods

In the present study, an oil-in-water nanoemulsion containing ibuprofen (NE-Ibu) was prepared and investigated for topical delivery of the drug. Carbopol 934 was used to produce a topical gel from NE-Ibu (NE-Ibu gel). Then, its anti-inflammation activity was evaluated in vivo and compared with commercial Ibu gel and topical gel of the corresponding micelle containing Ibu (i.e., MI-Ibu gel). Furthermore, skin permeation and serum concentration of the drug in the formulations were evaluated using HPLC.

Key Findings

The results showed that the anti-inflammatory activity of NE-Ibu gel and MI-Ibu gel increased in comparison to the commercial one. Also, serum concentration following application of NE-Ibu gel and MI-Ibu gel was not significantly different from the commercial preparation.

Conclusion

Arguably, the nanoemulsion and the micelle-based gels could enhance Ibu penetration through the skin and the preparations may be introduced as appropriate candidates for topical delivery of hydrophobic drugs.

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Acknowledgements

This research has been supported by Tehran University of Medical Sciences & Health Services grant no. 95-02-87-31989.

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Authors and Affiliations

  1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Fariba Esmaeili & Amir Amani

  2. Department of Medical Nanotechnology, Applied Biophotonics Research Center, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Hadi Baharifar

  3. Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran

    Amir Amani

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  1. Fariba Esmaeili
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  2. Hadi Baharifar
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  3. Amir Amani
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Correspondence to Amir Amani.

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Esmaeili, F., Baharifar, H. & Amani, A. Improved Anti-inflammatory Activity and Minimum Systemic Absorption from Topical Gels of Ibuprofen Formulated by Micelle or Nanoemulsion. J Pharm Innov 17, 1314–1321 (2022). https://doi.org/10.1007/s12247-021-09603-z

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