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Formulation and Evaluation of Cyclodextrin-Based Thermosensitive In Situ Gel of Azithromycin for Periodontal Delivery

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Abstract

Purpose

This study aims to formulate and evaluate the temperature-sensitive in situ gel of 0.5% (w/v) azithromycin (AZM) containing cyclodextrin inclusion complex by the cold method.

Method

To increase its aqueous solubility, it was incorporated as an inclusion complex in a 1:1 M ratio with hydroxypropyl β-cyclodextrin (HPβ-CD). The central composite design was used to optimize the effect of poloxamer 407 and Carbopol 934P (independent factors) on dependent factors such as percentage drug release at first hour (t50% and t90%), gelation temperature, and viscosity. Both the independent factors had a significant effect on the entire five response factors (p < 0.05). Each formulation was evaluated for clarity, pH, spreadability, syringeability, gelation strength, mucoadhesive property, in vitro drug release, gelation temperature, viscosity, and rheology.

Result

Based on maximum desirability, formulation containing 18.91% (w/v) of poloxamer 407 and 0.353% (w/v) of Carbopol 934P was considered an optimized batch. The value of percentage relative error exhibited a close agreement between observed and predicted values calculated using regression equations. Further, the optimized formulation showed a good drug release for a period of 54 h, which was more effective in the treatment of periodontal disease.

Conclusion

Thus, azithromycin (AZM) can be successfully formulated as a thermosensitive in situ mucoadhesive gel containing HPβ-CD for periodontal drug delivery.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, 360005, India

    Mihir Raval & Hina Bagada

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  1. Mihir Raval
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  2. Hina Bagada
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Correspondence to Hina Bagada.

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Raval, M., Bagada, H. Formulation and Evaluation of Cyclodextrin-Based Thermosensitive In Situ Gel of Azithromycin for Periodontal Delivery. J Pharm Innov 16, 67–84 (2021). https://doi.org/10.1007/s12247-019-09422-3

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