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Cellulolytic thermophilic microorganisms in white biotechnology: a review

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Abstract

Enzymes of microbial origin are of immense importance for organic material decomposition leading to bioremediation of organic waste, bioenergy generation, large-scale industrial bioprocesses, etc. The market demand for microbial cellulase enzyme is growing more rapidly which ultimately becomes the driving force towards research on this biocatalyst, widely used in various industrial activities. The use of novel cellulase genes obtained from various thermophiles through metagenomics and genetic engineering as well as following metabolic engineering pathways would be able to enhance the production of thermophilic cellulase at industrial scale. The present review is mainly focused on thermophilic cellulolytic bacteria, discoveries on cellulase gene, genetically modified cellulase, metabolic engineering, and their various industrial applications. A lot of lacunae are yet to overcome for thermophiles such as metagenome analysis, metabolic pathway modification study, search of heterologous hosts in gene expression system, and improved recombinant strain for better cellulase yield as well as value-added product formation.

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The authors are thankful to the funding agency “Science and Engineering Research Board (SERB), New Delhi (YSS/2014/000413) to carry out the research work.

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  1. Biomics and Biodiversity Lab., Centre of Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, 751003, India

    Kalpana Sahoo, Rajesh Kumar Sahoo, Mahendra Gaur & Enketeswara Subudhi

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  1. Kalpana Sahoo
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Sahoo, K., Sahoo, R.K., Gaur, M. et al. Cellulolytic thermophilic microorganisms in white biotechnology: a review. Folia Microbiol 65, 25–43 (2020). https://doi.org/10.1007/s12223-019-00710-6

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